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Flashcards in peripheral nerve disease Deck (10):
1

describe features of mono neuritis multiplex

multiple non-contiguous nerves
vasculitic or inflammatory
asymmetric weakness/sensory loss
distal > proximal weakness
usually painful

2

name several systemic diseases associated with mono neuritis multiplex

polyarteritis nodosa
Wegeners granulomatosis
rheumatoid arthritis
leprosy
diabetes
lupus
sarcoidosis
lyme disease

3

what are the 2 categories of polyneuropathies

axonal
demyelinating

4

what are the diseases associated with demyelinating polyneuropathies

Guillon Barre (AIDP)
Chronic inflammatory demyelinating polyneuropathy (CIDP)
Charcot Marie tooth 1a
NCV findings: reduced conduction velocities, prolonged latency

5

What are the diseases associated with Axonal polyneuropathies

Toxic, metabolic nutritional
NCV findings: reduced amplitude

6

Describe the important features of Guillain Barre

-rapid onset symmetric weakness
-monophasic and preipheral
-respiratory failure major risk
-ascending weakness
-paresthesias
-areflexia
-facial weakness
-autonomic symptoms
-associated with CMV, EBV, HIV, immunizations, surgery
-albumin cytologic dissociation

7

describe the important features of B12 deficiency polyneuropathy

degeneration of dorsal columns and spinal tract
loss of vibration/proprioception
large fiber nerve axonopathy
-paresthesias and stocking glove sensory loss

8

name the nutritional polyneuropathies

B12
pyroxine
niacin
thiamine
alcohol
copper

9

name the toxic polyneuropathies

chemotherapeutic agents (cisplatinum, vincristine, taxol)
isoniazid
organophosphates
heavy metals
alcohol

10

what are the important features of Charcot Marie Tooth

Demyelinating (Slow NCV)
autosomal dominant
duplication of PMP22
pes cavus
hammer toe
hypertrophy of peripheral nerves