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Flashcards in Pharm- 13 Deck (50)
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0

Which AA makes dopamine?

Tyr

1

Which enzyme converts Tyr --> L-DOPA?

Tyrosine hydroxylase

2

What is special about tyosine hydroxylase as far as the synthesis steps?

Its the rate-limiting step

3

What 2 substrates does tyrosine hydroxylase use to make L-DOPA from Tyr?

BH4 and O2

4

What enzyme converts L-DOPA --> Dopamine?

dopamine decarboxylase

5

What cofactor does dopa decarboxylase need?

PLP

6

Define: used to move a majority of DA back into the presynaptic cell; it’s a 12 transmembrane domain protein belongs to a family of catecholamine reuptake pumps

Dopamine Transporter (DAT)

7

True or false: Dopamine uses secondary active transport to get into the presynaptic cell.

True

8

What molecules does DA enter with into the cell throguh DAT?

Na+ and Cl-. (Na is the 1 that is made from the secondary active transport usign the Na/K ATPAase)

9

What transporter puts DA back into the synaptic vesicle?

VMAT

10

What 2 enzymes break down DA in the persynaptic terminal cytosol?

MAO and COMT

11

Which form of MAO (MAO-A or MAO-B) can degrade DA?

TRICK QUESTION LOL. Both can degrade DA.

12

Where is MAO-A expressed, brain or periphery?

GOT U AGAIN. ITS BOTH AHAHAHAHA

13

Where is MAO-B expressed, brain or periphery?

Just the brain.

14

So MAO-B inhibitors inhibit the breakdown of dopamine where?

CNS

15

What weird molecule in wine and cheese increases if you're taking an MAOi?

Tyramine

16

Where is COMT expressed?

Brain, heart, liver and kidneys

17

The breakdown of DA from COMT and MAO's break it down into which molecule?

HVA

18

Where can you test HVA to see the rate of DA breakdown?

Pee pee

19

D1- metabotropic or ionotropic

metabotropic

20

D1- Gs, Gq, or Gi?

Gs

21

D2- metabotropic or ionotropic?

metabotropic

22

D2- Gs, Gq, or Gi?

Gi

23

Which dopamine receptors are in the striatum (caudate and putamen)?

D1 and D2 (remember parkinsons???)

24

Which dopamine receptors are in the basal ganglia?

D1 and D2

25

Which dopamine receptors are in the substantia nigra?

D2 and D4

26

Which dopamine receptors are in the nucleus accumbens?

D1, D2, D3 (help with movement)

27

Which dopamine receptors are in the olfactory tubercle?

D1, D2, D3, D5

28

Which dopamine receptors are in the lactotrophs?

D2 (regulate prolactin secretion)

29

Where is the area postrema?

located in the floor of the fourth ventricle is also a target of dopamine therapies