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Flashcards in Pharm- 15 Deck (49)
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1

What causes focal seizures to be focal?

Focal seizure, or partial seizure, is named for the focal nature (surprise) of where the brain is affected. Surround inhibition (same principle as eye inhibition) keeps the seizure location localized to one spot

2

How does focal seizures increase in strength to cause generalized seizurres?

GABA inhibition isnt strong enough

3

What i the key feature to distinguish focal seizures from generalized seizures?

The pt retains consciousness

4

What are the Sx to focal szrs in the frontal lobe?

a wave-like sensation in the head; in the temporal lobe, a feeling of déjà vu (glitch in the matrix)

5

What happens in a complex focal szr?

szr starts in 1 part --> spreads --> Sx's spread accordingly.

6

What happens in secondary generalized szrs?

this type of seizure is bilateral due to spreading across the connections of the brain to the opposite hemisphere

7

What are the classical Sx of secondary generalized szrs?

loss of consciousness, and a tonic-clonic contraction of the body

8

What are the classical Sx of tonic-clonic (grand mal) szrs?

Loss of consciousness, and also as you would expect, intense contraction of both antagonist and agonist muscle groups.

9

What happens with the NMDA and AMPA receptors in the tonic phase?

They go super crazy

10

What happens to the AMPA and GABA receptors during the clonic phase?

They cycle back and forth,thats why u get jerky and spazzy

11

Where do absence szrs occur inth brain?

originate in a central location, and spreads to both hemispheres

12

What is the classical Sx of absence szrs?

characterized by a brief loss of consciousness

13

What is the mechanism to cause absence szrs?

T-type calcium channels, which are responsible for slow-wave sleep, so if they are activated, you just fall asleep right where you are. Somehow these calcium channels get activated inappropriately, leading to temporary loss of consciousness.

14

What are the 4 main mechanisms of anti-epileptic drugs (AEDs) to help wiht the Sx of szrs?

Drugs that increase Na+ channel inhibition
Drugs that inhibit calcium channels
Drugs that increase GABA mediated inhibition
Drugs that inhibit glutamate receptors

15

What is the mechanism to treat focal and general seizures?

treated via Na+ channel inactivation to stop channels, specifically channels that are cycling through open/closed states very quickly

16

What are the 4 drugs to treat local and secondary generalized seizures, which act on Na+ channels?

Phenytoin, Carbamazepine, Lamotrigine, and Valproic Acid

(VPLC)

17

What is the "use-dependent" mechanism of Phenytoin to treat szrs?

channels that are opened and closed at a high frequency, making them useless for slow, cyclical seizures such as Absence Seizures.

18

What % of phenytoin is bound to albumin in the blood?

95% bound to albumin

19

How is phenytoin metabolized in the body?

metabolized by the p450 hepatic system, and is an inducer of the p450 system (increases metabolism of fellow drugs metabolized by p450)

20

What is the T1/2 of phenytoin?

24 hour half life, because of its high albumin binding rate, if you give a patient too much, all of a sudden you may encounter very high levels of the drug in the plasma from virtually nothing before

21

What drug is an inducer of phenytoin?

Carbamezapine

22

What is an inhibitor of P450, causing the decreased metabolism of phenytoin?

Chloraamphenicol, Cimetidine, Disulfiram, Isoniazid

23

Phenytoin increases the metabolism of which drugs?

Oral contraceptives, quinidine, doxycycline, cyclosporine, methadone, levodopa

24

Why is carbamexapint pretty much the standard of choice for most patients that are also taking other drugs rather than phenytoin?

Linear metabolism

25

Why can Lamotrigine treat absence szrs better than phenytoin/carbamezapine?

due to its ability to affect High voltage Calcium channels

26

When do you use lacosamide?

Mechanism of action enhances slow inactivation of voltage gated sodium channels, and is another alternative to carbamazepine and phenytoin, especially for patients with drug-resistant epilepsy

27

Which tpye of Ca channels does ethosuximide block?

T-type calcium channels

28

What then does ethosuxamine treat>

absence szrs

29

Which type of Ca channels does valproic acid target?

blocks both T-type and High voltage calcium channels

30

Which Ca channels does gabapentin inhibit?

decreases release of excitatory neurotransmitter by inhibiting High Voltage calcium channels