Pharm 28 Flashcards
(41 cards)
What are the class ASEs of azole derivatives?
Increases LFT’s
Prolongs QTc
Inhibits CYP3A4
What are the available formulations of Clotrimazole?
Topical
Oral
What are the specific indications of Clotrimazole?
Candidia (cutaneous/oropharyngeal/vulvovaginal)
Tineas (unguium/pedis/corporis/capitis)
What are the available formulations of Fluconazole?
Oral
IV
What are the specific indications of Fluconazole?
Meningitis
Valley fever
What are the additional ASEs of Fluconazole?
Inhibits CYP2C9
Inhibits CYP2C19
What are the available formulations of Voriconzaole?
Oral
IV
What are the specific indications of Voriconazole?
Aspergillosis
Non-albicans invasive candida
What are the additional ASEs of Voriconazole?
Visual changes
Hepatotoxicity
What are the available formulations of Posaconazole?
Oral
IV
What are the specific indications of Posaconazole?
Mucormycosis
What are the additional ASEs of Posaconazole?
Thrombophlebitis
What are the available formulations of Itraconazole?
Oral
What are the available formulations of Isavuconazonium?
Oral
IV
What is the ending common to all drugs in the echinocandins class?
“-fungin”
What are the available formulations of all drugs in the echinocandins class?
Parenteral only
What are the specific indications of all drugs in the echinocandins class?
Invasive candida
Invasive aspergillosis
What are the available formulations of Amphotericin B?
Oral IV IM/SubQ Aerosolization Intraperitoneal Intravitreal Intrathecal
What are the specific indications of Amphotericin B?
Yeast refractory to tx
Mold refractory to tx
What are the ASEs of Amphotericin B?
Nephrotoxicity Hepatotoxicity Electrolyte abnormalities (K, Na, Mg) Arrhythmias Pancytopenia
What are the benefits to using lipid formulations of Amphotericin B (Amphotericin B Lipid complex/Lipidosomal Amphotericin B)?
Less nephrotoxicity
What are the available formulations of Nystatin?
Topical
Oral
What are the specific indications of Nystatin?
Candida
What are the available formulations of Terbinafine?
Topical
Oral
