Pharm antineoplastic Agents III, Intercalation/Oxidative scission

Question 1

Antibiotics (class): Bleomycin, Dactinomycin (low yield?) (members) MOA and what phase of the cell cycle

Answer 1

• Fe (+2/+3) mediated free radical generation (superoxide/HYDROXY RADICALS)–DNA strands break
• G2 phase

Question 2

*Anthracyclines (class): Doxorubicin ( or any -rubicin) MOA and what phase of the cell cycle

Answer 2

• INHIBIT TOPOISIMERASE II
• FREE RADICAL generation (superoxide/ HYDROGEN PEROXIDE)–DNA strand breaks
• -DNA intercalating agents
• S-phase

Question 3

Anthracyclines (class): Mitoxantrone (low yield?) (members) MOA

Answer 3

-Inhibit topoisomerase II

Question 4

Bleomycin uses

Answer 4

-testicular cancer (with other drugs)

Question 5

Doxorubicin (all -rubicin) uses

Answer 5

-breast, ovarian (lots of others)

Question 6

Mitoxantrone uses

Answer 6

-breast, prostate, non-Hodgkins lymphoma

Question 7

*Bleomycin Dose limiting Toxicity

Answer 7

-PULMONARY FIBROSIS

Question 8

*Doxyrubicin (and all -rubicin) Dose Limiting Toxicity

Answer 8

-CARDIOTOXICITY, DIALATED CARDIOMYOPATHY, CHF

Question 9

Mitoxantrone Dose Limiting Toxicity (low yield?)

Answer 9

CARDIOTOXICITY, DIALATED CARDIOMYOPATHY, CHF