Pharm Antiviral for skin lesions, Nucleosides Flashcards

-Host cell kinases means the Host is having to do most of the work, which is not as effective -Viral activation, is much more effective

1
Q

*Valcyclovir (prodrug thats oral) turns into what parent drug, and what is the viral activation? What type of analog?

A

Acyclovir. Herpes Simplex Virus/ HZV:Thymidine kinase, -mono P
-Guanosine analog

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2
Q

Valcyclovir cell activation

A

Host cell kinases -di P, -tri P

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3
Q

*Famciclovir (prodrug that oral) turns into what parent drug, and what is the viral activation? What type of analog?

A

Penciclovir (HSV ONLY). Herpes Simplex Virus/HZV thymidine kinase, -mono P

  • FAMCICLOVIR CAN TREAT HSV AND VZV
  • Guanosine analog
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4
Q

Famciclovir cell activation

A

-Host cell kinases -di P, -tri P

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5
Q

*Valganciclovir (prodrug thats oral) turns into what parent drug, and what is the viral activation? What type of analog?

A

Ganciclovir. CMV UL97 kinase, -mono P

-Guanosine analog

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6
Q

Valganciclovir Cell activation

A

Host cell kinases, -di P, -tri P

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7
Q

Cidofovir viral activation

A

none needed

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8
Q

*Cidofovir cell activation

A

HOST CELL KINASES, -mono p, -di P, -tri P

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9
Q

Vidarabine viral activation

A

None needed

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10
Q

Vidarabine cell activation and what type of analog

A

Host cell kinases -mono P, di P, -tri P

-Adenosine analog

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11
Q

Trifluroidine cell activation

A

host cell kinases, -mono P, -di P, -tri P

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12
Q

Trifluroidine viral activation

A

None needed

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13
Q

*Acyclovir uses

A

HSV, VZV (-Zoster)

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14
Q

*Valacyclovir uses

A

HSV, VZV

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15
Q

*Penciclovir uses

A

HSV only

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16
Q

*Famciclovir uses

A

HSV, VZV

17
Q

*Vidarabine or Trifluoridine uses

A
  • HSV, VZV

- HSV topical ophthalmic ONLY

18
Q

*Foscarnet uses, activation, ADR

A
  • Acyclovir RESISTANT HSV/VZV, CMV RETINITIS
  • NO ACTIVATION REQUIRED
  • Nephrotoxic, hypocalcemia
19
Q

Ganciclovir Toxicity and pregnancy category

A
  • Bone marrow suppression

- Class C

20
Q

*Cidofovir ADR

A

-NEPHOTOXICITY or those taking non-steroidal anti-inflammatory

21
Q

*Docosanol use

A
  • SHORTENS HEALING TIME

- aka Abreva