Pharm - Antivirals - General Flashcards
(17 cards)
influenza drugs
zanamivir
oseltamivir
CMV drugs
ganiciclovir
valganciclovir
foscarnet
Cidofovir
M2 inhibitors
amantadine
rimantadine
interferons
use
hep B and C
kaposi sarcoma
herpes drugs
acyclovir
famciclovir
valacyclovir
zanamivir
MOA/AE
MOA: inhibit neuroaminidase (essential in virus release)
*effective only w/I first 48hr
AE: bronchospasm
oseltamivir
MOA/AE
MOA: inhibit neuroaminidase (essential in virus release)
AE: GI upset, delirium (CHILD)
amantadine
MOA/AE
MOA: inhibits M2 (present on influenza A only)
AE: CNS (insomnia, hallucinations), resistance via a single aa mutation in M2 protein
rimantadine
MOA/AE
MOA: inhibits M2 (present on influenza A only)
AE: resistance via a single aa mutation in M2 protein
acyclovir
MOA/AE
MOA: inhibits herpes virus DNAP (mimics guanine –> term chain growth)
*requires P to mono-P by virus kinase, to tri-P by host kinases (resistance via this req)
AE:
nephrotoxicity
neurotoxicity
acyclovir
use
HSV-1
HSV-2
VZV
valacyclovir
MOA
pro-drug, cons to acyclovir
greater bioavailability
ganciclovir
MOA/AE
MOA: sim to acyclovir
*requires P to mono-P by virus kinase, to tri-P by host kinases (resistance via this req)
AE:
BM suppression (leukopenia)
Nephrotoxicity
valganciclovir
MOA/AE
pro-drug, conv to gancyclovir in intestine
AE:
BM suppression
foscarnet
MOA/AE
MOA: inhibits DNAP (pyrophosphate analog)
(NO phos req)
AE: nephrotoxicity hypOK hypOCa hypOMg seizures
foscarnet
use
resistant HSV, CMV, VZV
but TOXIC
should be co-admin w/ probenecid
cidofovir
coadmin w/ probenecid and IV saline to dec nephrotoxicity
