Pharm - Malaria - General

Question 1

quinolone derivatives for TB

Answer 1

chloroquine
mefloquine
primaquine 
quinidine
tafenoquine

Question 2

antifolate compounds for TB

Answer 2

pyrimethamine
sulfonamides
proguanil

Question 3

Artemisinin derivatives for TB

Answer 3

atemisinin

artesunate

Question 4

abx for TB

Answer 4

clindamycin
atovaquone
doxycycline

*always used in combo w/ other agents

Question 5

quinine and quinidine

Answer 5

not used clinically anymore - if they are, must give w/ clindamycin or doxycycline

AE: QT prolong

Question 6

chloroquine

MOA/AE/use

Answer 6

MOA: blocks plasmodium heme synthesis

AE: pruritus in dark skinned, exacerbation of psoriasis, irreversible retinopathy

use: sensitive malaria (NOT P. falc (resistance too high)

Question 7

mefloquine

AE/use

Answer 7

AE: neuropsychiatric (avoid if mental health hx), QT prolong

use: prophylaxis and tx of resistant malaria

Question 8

primaquine

AE/use

Answer 8

AE: acute hemolysis if G6PD, avoid in pregnancy

use: prevention of relapse malaria

Question 9

tafenoquine

AE/use

Answer 9

AE: acute hemolysis if G6PD, avoid in pregnancy/mental illness hx

use: NEW, prophylaxis and cure

Question 10

combination taken daily for prophylaxis/tx of Pf

Answer 10

atovaquone/proguanil

AE: contraindicated w/ renal dysfunction

Question 11

artesunate

AE/use

Answer 11

AE: gen well tolerated

use: in COMBO for uncomplicated, or IV for severe malaria (first line)

Question 12

severe pf, chloroquine resistant

Answer 12

artesunate (IV)

Question 13

If G6PD, avoid

Answer 13

primaquine