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Pharma; Restart > Pharma Halo-halo, CNS > Flashcards

Pharma Halo-halo, CNS Flashcards

1
Q

Rivastigmine class

A

Indirect-acting cholinomimetics

Acethylcholinesterase inhibtor

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2
Q

Classmates of rivastigmine

A

Dan (Donepezil)
Gayle (Galantamine)
Tucker (Tacrine)

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3
Q

Remarks on rivastigmine

A

Available as transdermal patch 📌

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4
Q

Remarks on donepezil

A

Combined with memantine (NMDA antagonist) for Alzheimer’s dementia

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5
Q

Bentropine moa

A

Muscarinic antagonist (non-selective)

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6
Q

Classmates of benztropine

A

Biperiden

Trihexyphenidyl

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7
Q

Antiviral used for parkinsonism

A

Amantadine

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8
Q

Remarks on amantadine

A

Prevents uncoating by binding to M2 proton channels
For influenza A only
May cause livido reticularis, crebellar dysfunction

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9
Q

What drugs may cause livido reticularis

A 
A man reads FHM and GQ
Amantadine
Hydroxyurea
Minocycline
GEmcitabine
Quinidine
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10
Q

Pathologic hallmark of PD

A

Loss of dopaminergic neurons of the substantia nigra pars compacta, with appearance of intracellular inclusions LEWY BODIES (containe a-synuclein) 🔥

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11
Q

Remarks on Levodopa-Carbidopa

A

Carbidopa: suicide to dopa decarboxylase

Hypertensive crisis occurs when used with MAOi

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12
Q

Ergot dopamine agonists

A 
Bromocriptine
Pergolide (cardiac fibrosis)
Cabergoline
Piribedil
*valvular and lung fibrosis
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13
Q

S/e of bromocriptine

A

Erythromelalgia (burning pain and warmth and redness of extremities)
Pulmonary infiltrate

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14
Q

Drugs that cause pulmonary fibrosis

A 
Bromocriptine
Bleomycin
Busulfan
Amiodarone
Nitrofurantoin
Methotrexate
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15
Q

Non-ergot dopamine agonists

A

Pramipexole
Ropinirole
For restless leg syndrome

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16
Q

Remarks on pramipexole

A 
Compulsive gambling
Hypersexuality
Overeating
Sleep tendencies
*impulse control disorders are attributed to the activation of D2/D3 receptors in the mesolimbic pathways of the brain
17
Q

Opioid dopamine agonist

A

Apomorphine

18
Q

Rabbit syndrome

A

Perioral tremor

Tx: benztropine

19
Q

Mao B inhibitors

A

Selegiline

Rasagiline

20
Q

Remarks on Mao B inhibitors

A

If used with meperidine, causes agitation, delirium and death
Serotonin syndrome occurs when used with SSRI, TCA, meperedine
No Cheese effect (hypertensive crisis with ingestion of tyramine rich food)

21
Q

COMT inhiitor

A

Catechol-O-methyltransferase inhibitors
Entacapone (peripheral only)
Tolcapone (peri, cns)

22
Q

Remarks on COMT inhibitors

A

Orange urine
Hepatotoxicity (tolcapone)
Rhabdomyolysis

23
Q

Another classmate of benztropine

A

Procyclidine

24
Q

Drugs that cause rhabdomyolysis

A

Tolcapone
Entecapone
Statin/fibrate 📌

Pharma; Restart (11 decks)

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