Pharma SF

Question 1

color blindness in ethambutol toxicity

Answer 1

red-green color blindness

also the most common cause of color blindness worldwide

Question 2

toxicity of PTU

Answer 2

liver toxicity

Question 3

used prior to thyroid surery

Answer 3

potassium iodide

Question 4

theophilline class, MOA, s/e

Answer 4

METHYLXANTHINE
MOA
-inhibits phosphodiesterase
-inc cAMP
-dec intracellular Ca++
-bronchodilation

NARROW THERAPEUTIC INDEX
m/c: nausea
others: cardiotoxicity, neurotoxicity

Question 5

drugs indicated for ganciclovir-resistant CMV

Answer 5

foscarnet and cidofovir

Question 6

drugs indicated for acyclovir-resistant HSV

Answer 6

foscarnet and cidofovir

Question 7

s/e of resperidone

Answer 7

hyperprolactinemia
gynecomastia
amenorrhea
gynecomastia
ªqt prolongation

ªall atypical antipsychotics cause QT prolongation

Question 8

atypical antipsychotic that cause seizures

Answer 8

clozapine

-obesity, agranulocytosis

Question 9

opioid receptors

Answer 9

kappa
Mu
Delta

Question 10

opioid receptor responsible for development of tolerance to opioids

Answer 10

delta receptor

Question 11

opioid receptor responsible for slowing of GI motility

Answer 11

Mu and Kappa

Question 12

opioid receptors that are responsible for respiratory depression

Answer 12

Mu receptors

Question 13

opioid receptors that are responsible for sedation

Answer 13

Kappa receptor

Question 14

levofloxacin is what generation

Answer 14

3rd generation

also
Moxifloxacin
gemifloxacin
gatifloxacin
sparfloxacin

Question 15

what are 2nd generation fluoroquinolones

Answer 15

“CLONE”

ciprofloxacin
lomefloxacin
ofloxacin
norfloxacin
enoxacin

Question 16

what are 1st generation fluoroquinolones

Answer 16

nalidixic acid
oxolinic acid
cinoxacin

Question 17

what are 4th gen fluoroquinolones

Answer 17

clinafloxacin
trovafloxacin

/the higher thegeneration, the higher the activity vs gram positives/

Question 18

drugs that can cause serotonin syndrome

Answer 18

tramadol
ondansetron
dextromethorphan
ªBuspirone
Triptans
Linezolid
MDMA

NOT ibuprofen (NSAIDs)

ªBUSPIRONE MOA: 5-HT1A partial agonist, D2 agonist (nonbenzodiazepine anxiolytic)

Question 19

Symptoms of serotonin syndrome

Answer 19

3As

ACTIVITY (seizures, tremors, spasticity)

AUTONOMIC INSTABILITY (hyperthermia, diarrhea, diaphoresis)

ALTEREDMENTAL STATUS

Question 20

unfamiliar NSAIDs

Answer 20

“PaPa, DoN’T”

Piroxicam
Phenylbutazone

Diclofenac
Nabumetone
Tolmetin