Pharma SF Flashcards
(20 cards)
color blindness in ethambutol toxicity
red-green color blindness
also the most common cause of color blindness worldwide
toxicity of PTU
liver toxicity
used prior to thyroid surery
potassium iodide
theophilline class, MOA, s/e
METHYLXANTHINE MOA -inhibits phosphodiesterase -inc cAMP -dec intracellular Ca++ -bronchodilation
NARROW THERAPEUTIC INDEX
m/c: nausea
others: cardiotoxicity, neurotoxicity
drugs indicated for ganciclovir-resistant CMV
foscarnet and cidofovir
drugs indicated for acyclovir-resistant HSV
foscarnet and cidofovir
s/e of resperidone
hyperprolactinemia gynecomastia amenorrhea gynecomastia ªqt prolongation
ªall atypical antipsychotics cause QT prolongation
atypical antipsychotic that cause seizures
clozapine
-obesity, agranulocytosis
opioid receptors
kappa
Mu
Delta
opioid receptor responsible for development of tolerance to opioids
delta receptor
opioid receptor responsible for slowing of GI motility
Mu and Kappa
opioid receptors that are responsible for respiratory depression
Mu receptors
opioid receptors that are responsible for sedation
Kappa receptor
levofloxacin is what generation
3rd generation
also Moxifloxacin gemifloxacin gatifloxacin sparfloxacin
what are 2nd generation fluoroquinolones
“CLONE”
ciprofloxacin lomefloxacin ofloxacin norfloxacin enoxacin
what are 1st generation fluoroquinolones
nalidixic acid
oxolinic acid
cinoxacin
what are 4th gen fluoroquinolones
clinafloxacin
trovafloxacin
/the higher thegeneration, the higher the activity vs gram positives/
drugs that can cause serotonin syndrome
tramadol ondansetron dextromethorphan ªBuspirone Triptans Linezolid MDMA
NOT ibuprofen (NSAIDs)
ªBUSPIRONE MOA: 5-HT1A partial agonist, D2 agonist (nonbenzodiazepine anxiolytic)
Symptoms of serotonin syndrome
3As
ACTIVITY (seizures, tremors, spasticity)
AUTONOMIC INSTABILITY (hyperthermia, diarrhea, diaphoresis)
ALTEREDMENTAL STATUS
unfamiliar NSAIDs
“PaPa, DoN’T”
Piroxicam
Phenylbutazone
Diclofenac
Nabumetone
Tolmetin
