PHARMA PRACTICE PROBLEMS Flashcards
How many capsules, each containing 250mg of clarithromycin, are needed to provide 50 mg/kg/day for 10 days for a person weighing 176 lb?
a. 150 clarithromycin capsules
b. 180 clarithromycin capsules
c. 160 clarithromycin capsules
d. 120 clarithromycin capsules
B. 160 clarithromycin capsules
If the pediatric dose of dactinomycin is 15 mcg/kg/day for 5 days, how many micrograms should be administered to a 40-lb. child over the course of treatment?
a. 1354 mcg dactinomycin
b. 1364 mcg dactinomycin
c. 1340 mcg dactinomycin
d. 1360 mcg dactinomycin
B. 1364 mcg dactinomycin
If the administration of gentamicin at a dose of 1.75mg/kg is determined to result in peak blood serum levels of 4 mcg/mL, calculate the dose, in milligrams, for a120-lb. patient that may be expected to result in a blood serum gentamicin level of 4.5 mcg/mL.
a. 102.2 mg gentamicin
b. 107.39 mg gentamicin
c. 100 mg gentamicin
d. 100.52 mg gentamicin
B. 107. 39 mg gentamicin
A medication order calls for tobramycin sulfate, 1 mg/kg of body weight, to be administered by IM injection to a patient weighing 220 lb. Tobramycin sulfate is available in a vial containing 80 mg per 2mL. How many milliliters of the injection should the patient receive?
a. 1.2 ml tobramycin injection
b. 3.4 ml tobramycin injection
c. 2.5 ml tobramycin injection
- 5 mL tobramycin injection
The usual pediatric dose of acyclovir is 20 mg/kg administered by infusion and repeated every 8 hours. What would be the single dose, in milligrams, for a child weighing 33 lb.?
a. 100 mg acyclovir
b. 200 mg acyclovir
c. 300 mg acyclovir
300 mg acyclovir
If the adult dose of a drug is 100 mg, what would be the dose for a child with a body surface area of 0.70 m2?
a. 40.40 mg
b. 40. 46 mg
c. 23.45 mg
- 46 mg
If the adult dose of a drug is 25 mg, what would be the dose for a child weighing 40 lb. and measuring 32 in. in height?
a. 8.53 mg
b. 9.53 mg
c. 8.54 mg
- 53 mg
If the dose of a drug is 10 mg/m2 per day what would be the daily dose, in milligrams, for a child weighing 30 lb. and measuring 26 in. in height?
a. 4.3 mg
b. 4.4 mg
c. 4.5 mg
d. 3.4 mg
4.5 mg
If the dose of a drug is10 mg/m2 per day what would be the daily dose, in milligrams, for a child weighing 30 lb. and measuring 26 in. in height?
a. 35.4 mg mitomycin
b. 20.4 mg mitomycin
c. 24.5 mg mitomycin
35.4 mg mitomycin
An anticancer treatment includes methotrexate,35 mg/m2 of body surface area once per week for 8 weeks. How many grams of methotrexate would a 150-lbpatient, 5 ft. 8 in. tall, receive during this course of therapy?
a. 0.504 g methotrexate
b. 0.654 g methotrexate
c. 0.234 g methotrexate
0.504 g methotrexate
A four-agent dosage regimen, termed MOPP, for the treatment of Hodgkin lymphoma includes the following drugs taken over a 28-day cycle:
*Mechlorethamine 6 mg/m2, I.V., D1 & 8
*Vincristine 1.4 mg/m2, I.V.,D 1 & 8
*Procarbazine 100 mg/m2/d, p.o., D1 to 4
*Prednisone 40 mg/m2/d, p.o., D1 to 4
Calculate the total number of20-mg tablets of prednisone and 50-mg tablets of procarbazine to dispense to treat a patient with a BSA of 1.5 m2 during the course of one treatment cycle
42 procarbazine tablets, 42 prednisone tablets
The oncolytic agent lapatinib (TYKERB)is administered in the treatment of breast cancer in daily doses of 1250 mg for 21consecutive days in combination with the drug capecitabine (XELODA), which is administered in doses of 1000 mg/m2/day during days 1 to 14 of the 21-day treatment cycle. Calculate the total quantity of each drug to be administered during the treatment cycle to a 5′2_ woman weighing110 pounds
26.25 g lapatinib, 20.72 g capecitabine
Among the single chemotherapy agents for breast cancer is docetaxel (TAXOTERE) which is administered 40 mg/m2 IV weekly for 6 weeks followed by a 2week rest and then repeated. Calculate the total dose administered during the initial 6-week period to a patient 5′4 tall and weighing 160 pounds.
434.9 mg docetaxel
