Pharmacogenetics side effects and contradictions

Question 1

Hypokalemia
Dehydration
Hyperglycemia
Hyperuricemia
Reduction of HDL cholesterol
Increase in LDL cholesterol and triglycerides
Gout
dyslipidemia

Contridictions:
Drug effects:
Digoxin
Ototoxic drugs
Potassium-sparing diuretics
Lithium
Antihypertensive agents
NSAIDs

Answer 1

Thiazide Diuretic
Hydrochlorothiazide

Question 2

Reduction of HDL cholesterol
Increase in LDL cholesterol and triglycerides
Gout
dyslipidemia

Hyponatremia
Hypochloremia
Hypotension
Hypokalemia
Dehydration
Ototoxicity
Electrolyte imbalance

Contradictions:
aminoglycoside antibiotics

Answer 2

Loop Diuretic
Furosemide

Question 3

Side effects

Hyperkalemia
Endocrine Effects
dyslipidemia.
Contradictions:
They must not be used with ACE inhibitors, angiotensin II receptor blockers, or aldosterone antagonists, which promote significant hyperkalemia.

Answer 3

Potassium Sparing Diuretic
Spironolactone

Question 4

bradycardia, reduced cardiac output, AV heart block, and rebound cardiac excitation after abrupt withdrawal
hypoglycemia
Erectile dysfunction
Fatigue dizziness
dyslipidemia.
Erectile dysfunction
Contradictions:
sinus bradycardia
AV block greater than first degree
Diabetes mellitus

Answer 4

Beta Blockers: Cardioselective
Metoprolol

Question 5

Side effects:

Bronchi constriction
Diabetes mellitus
dyslipidemia.
Hyperglycemia
Hyperkalemia
Contradictions:
Do not use in patients with bradycardia hypotension and decompensated heart failure or 2nd

Answer 5

Beta Blockers
Non-Selective
Propranolol

Question 6

Side effects

Headache
dizziness
orthostatic hypotension, reflex tachycardia, nasal congestion, and inhibition of ejaculation

Contradiction : Older adults

Answer 6

Alpha 1 Adrenergic Receptor Blockers:
Doxazosin

Question 7

Exacerbate bradycardia AV heart block
Asthma
Postural hypotension
dyslipidemia.

Contradictions:
Aggravates bronchial asthma, heart failure, AV block, cardiogenic shock, and bradycardia
It should not be given to patients with these disorders.

Answer 7

Alpha & Beta Adrenergic Receptor Antagonists:
Labetalol

Question 8

severe rebound hypertension
Hemolytic anemia
Liver disorders
Bradycardia
Nausea
Dry mouth
HF
Drug Reactions:
Beta blockers – Bradycardia

Tricyclic antdep and monoamine oid inhibiter – anti-hypertensive effects

Contradictions:
Caution in older, pregnant, renal function

Answer 8

Centrally acting alpha 2 agonist:
Clonidine ( treat withdrawals) also prevent migraines
Methyldopa (treat hypertensive crisis)