Pharmacokinetics and Pharmacodynamics Flashcards Preview

Apex 5 - 3 Neuromuscular Blockers Reversal Agents (5) > Pharmacokinetics and Pharmacodynamics > Flashcards

Flashcards in Pharmacokinetics and Pharmacodynamics Deck (34)
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1

Which statements regarding anticholinesterase drugs are true? (Select 2.)

Study on!!!

2

The dose of Edrophonium is --- to --- mg/kg

0.5 - 1.0 mg/kg

3

The Onset of Edrophonium is --- to --- min

1 - 2 min

4

The Duration of Edrophonium is --- to --- min

30 - 60 min

5

The Metabolism & Elimination of Edrophonium are --- % Renal and --- % Liver

75% Renal25% Liver  

6

Edrophonium is best paired with which anticholinergic?

Atropine

7

The dose of Neostigmine is --- to --- mg/kg

0.02 - 0.07 mg/kg

8

The Onset of Neostigmine is --- to --- min

5 - 15 min

9

The Duration of Neostigmine is --- to --- min

45 - 90 min

10

The Metabolism & Elimination of Neostigmine are --- % Renal and --- % Liver

50% Renal50% Liver  

11

Neostigmine is best paired with which anticholinergic?

Glycopyrrolate

12

The dose of Pyridostigmine is --- to --- mg/kg

0.1 - 0.3 mg/kg

13

The Onset of Pyridostigmine is --- to --- min

10 - 20 min

14

The Duration of Pyridostigmine is --- to --- min

60 - 120 min

15

The Metabolism & Elimination of Pyridostigmine are --- % Renal and --- % Liver

75% Renal 25% Liver   

16

Pyridostigmine is best paired with which anticholinergic?

Glycopyrrolate

17

Renal failure ----- the duration of action for both AchE inhibitors and NMBs

"prolongs"

18

Renal failure prolongs the duration of action for both AchE inhibitors and NMBs. Since both drugs will remain in the body for a longer period of time, there is no need to adjust the dose of the AchE inhibitor or re-dose it

True

19

AchE inhibitors have a ----- effect above which additional drug does not produce a better recovery

Ceiling effect

20

The onset of action is directly related to the ----- of the block

"depth"

21

The onset of action is directly related to the depth of the block. For example, neostigmine will take ----- to  reach peak effect with a 90% twitch suppression when compared to a 50% twitch suppression

"longer"

22

Mixing AchE inhibitors yields:

A. an additive effect

B. a synergistic effect

Additive effect

(not synergistic)

23

When compared to adults, antagonism with Neostigmine is ----- in infants and children

"faster"

24

Edrophonium, neostigmine, and pyridostigmine are quaternary amines - they ----- the blood-brain barrier

A. cross

B. do not pass through

"do not pass through"

25

Physostigmine is a tertiary amine - it ----- the blood-brain barrier

A. crosses

B. does not pass through

"Crosses"

26

Which AChE inhibitor administered intrathecally (50 - 100 mcg) produces analgesia

 Neostigmine

27

Intrathecal Neostigmine (50 -100 mcg) produces analgesia. Side effects include:

Nausea and vomiting

Pruritus

Prolongation of sensory and motor block

28

Intrathecal Neostigmine (50 -100 mcg) produces analgesia. Side effects include nausea and vomiting, pruritus, and ----- of sensory and motor block

"Prolongation"

29

Which AChE inhibitor (40 mcg/kg) reduces the incidence of postoperative shivering

Physostigmine

30

Physostigmine (40 mcg/kg) reduces the incidence of postoperative shivering. Its efficacy matches ----- and -----.

Meperidine and Clonidine