Pharmacology Flashcards
(32 cards)
Oxytetracycline MOA
Binds 30S subunit of bacterial ribosome. Blocks attachment of aminoacyl-tRNA to A site on ribosome.
Half life of ergometrine
30-120 minutes
Half life of oxytocin
5 minutes
Half life of misoprostal
20-40 minutes
Metronidazole mechanism of action
Inhibits nucleic acid synthesis via radical formation
Drug causes of raised prolactin
Atypical antipsychotics (risperidone)
Phenothiazines (chlorpromazine)
Haloperidol
Metoclopramide
Methyldopa
Catecholamine depletors (Reserpine)
Opiates
H2 antagonists (Ranitidine)
Amitriptyline
SSRIs
Calcium channel blockers
Oestrogens
Thyrotropin-releasing hormone
Promethazine MOA
Antihistamine
H1 receptor antagonist
Ranitidine MOA
H2 blocker
Mifepristone MOA in termination of pregnancy
Anti progestogen
Quinolone MOA
DNA Gyrase inhibition
Quinolone = ofloxacin
Terbinafine MOA
Inhibition of squalene epoxidase
Lidocaine MOA
Blockage of fast gated Na channels
Cerazette MOA
Inhibition of ovulation
Clomiphene MOA
Selective oestrogen receptor modulator
Morphine MOA
Mu receptor agonism
TXA MOA
Inhibits activation of plasminogen
Which clotting factors does warfarin inhibit?
2, 7, 9, 10
Clindamycin MOA
Interference with protein synthesis (binds to ribosome sub units)
Clotrimazole MOA
Bind phospholipids in fungal cell wall
Prevent production of ergosterol
All imidazoles work in this way
Lidocaine max dose
3mg/kg
OR
7mg/kg if given with adrenaline
Prochlorperazine MOA
Dopamine D2 antagonist
(Hence why can’t be given in Parkinson’s)
Clomifene MOA
Oestrogen receptor antagonism in hypothalamus
Bromocriptine MOA
D2 (dopamine) receptor agonism
Used in acromegaly and treatment of prolactinomas
Mirabegron MOA
Selective B3 adrenergic receptor AGONIST
