Pharmacology

Question 1

Clinical features of MDMA

Answer 1

tachycardia and hypertension
agitation
low sodium
high temp

Question 1

Which drug class can precipitate dig toxicity

Answer 1

Thiazides such as indapamide

Question 2

What visual change might you see in dig toxicity

Answer 2

yellow green vision

Question 3

Which drugs can cause dig toxicity

Answer 3

Thiazides
Amiodarone
Quinidine
Verapamil
Diltiazem
Spiro

Question 4

MOA of cocaine

Answer 4

blocks uptake of dopamine, noradrenaline, serotonin

Question 5

Nitrofurantoin is best avoided at what CKD level

Answer 5

3

Question 6

Management of organophosphate poisining

Answer 6

Atropine

Question 7

How do macrolides work

Answer 7

inhibit protein synthesis by blocking translocation
bacteriostaticW

Question 8

which of the RIPE drugs affect p450 system

Answer 8

Rifampicin (rifAMPicin)
Isoniazid (inhibits)

Question 9

MOA aspirin

Answer 9

None-reversible COX1 and 2 inhibitor

Question 10

Monitoring of the following drugs

Statins
ACEi
Amiodarone

Answer 10

Statin: LFT 0, 3, 6 months
ACEi: UEs before, dose change, annually
Amiodarone: TFT LFT before (+UE CXR) and every 6 months

Question 11

Sodium valproate monitoring

Answer 11

LFTs periodically through first 6 months

Question 12

MOA metformin

Answer 12

increased insulin sensitivity
decreases hepatic gluconeogenesis

Question 13

Side effects of sulfonIDEureas

Answer 13

hypos
weight gain
SIADH
liver dysfucntion

Question 14

Side effects of glitazones

Answer 14

weight gain
fluid retention
liver
fractures

Question 15

which diabetic drug class can cause pancreatitis

Answer 15

gliptins

Question 16

Which electrolyte abnormalities can cause dig toxicity

Answer 16

low K
low Mg

high Na
High Ca

Question 17

How does allopurinol work?

Answer 17

Inhibits xanthine oxidase

Question 18

Memory aid for RIPE drugs

Answer 18

Rifampicin - red/orange
Isoniazid - ‘i’nhibits liver, ‘i’ns and needles
Pyrazinamide - ‘p’ainful joints
Ethambutol - ‘E’yes

Question 19

Which anti seizure drug can auto-induce itself

Answer 19

Carbamazapine

Question 20

Side effects of the following drugs

Amox
Fluclox
Co-amox
Erythro
Cipro
Metro
Doxy

Answer 20

Amox - rash with IM
Fluclox - cholestasis
Co-amox - cholestasis
Erythro - prolonged QT
Cipro - tendinitis
Metro - reaction with alcohol
Doxy - photosensitivity

Question 21

In what situations should continuous HRT be given

Answer 21

1. LMP > 1year ago
2. Been on cyclical for more than 1 year
3. LMP > 2 years in premenopausal women

Question 22

Drug of choice for nausea related migraine

Answer 22

Metoclopramide

Question 23

which ppi should not be prescribed if taking clopidogrel

Answer 23

omeprazole
esomeprazole

Question 24

What should be monitored in haemochromatosis treatment?

Answer 24

transfern saturation serum ferritin

Question 25

TIBC is high in haemochromatosis

Answer 25

false. low

Question 26

risk factors for SCC of the oesophagus

Answer 26

smoking alcohol achalasia

Question 27

Risk factors for adenocarcinoma of the oesophagus

Answer 27

GORD Barrett smoking fat

Question 28

Which situations is TIBC raised

Answer 28

IDA pregnancy oestrogen

Question 29

Formula for units in a volume

Answer 29

ABV X volume / 1000

Question 30

Antibodies seen in Primary Biliary Cirrhosis

Answer 30

AMA

Question 31

Which drug can help with pruritus in PBC

Answer 31

cholestyramine

Question 32

deranged liver function and amenorrhea

Answer 32

autoimmune hep

Question 33

indications for spiro use

Answer 33

ascites hypertension: used in some patients as a NICE 'step 4' treatment heart failure nephrotic syndrome Conn's syndrome

Question 34

these drugs should be avoided with SSRIs

Answer 34

titans aspirin MAOIs warfarin and heparin

Question 35

which SSRI are associated with long qt

Answer 35

citalopram

Question 36

Antidepressant often used in the elderly

Answer 36

Mirtazapine

Question 37

Effect of quinolones on seizure threshold

Answer 37

Lowers threshold

Question 38

Patients allergic to aspirin may also react to this anti rhemumatic drug

Answer 38

Sulfasalazine