Pharmacology

Question 1

Why does phenoxybenzamine cause and increased HR?

Answer 1

it is a non-specific alpha blocker (alpha-1 and alpha-2 receptor antagonist) that can result in increase HR due to loss of alpha-2 pre-synaptic inhibition of NE release

Question 2

Which opioid has increased clearance in neonates/infants compared to adults and decreases with age?

Answer 2

remifentanil

Question 3

Which agent does not require adjustment of the set concentration at altitude?

Answer 3

sevoflurane; modern variable bypass vaporizer which delivers a constant partial pressure regardless of ambient pressure