Pharmacology 3 Chemotherapy Flashcards
(131 cards)
1
Q
Innefective againsta candida
A
TOLNAFTATE
2
Q
Worms present in humans but not animals
A
ASCARIS
ANCLYSTOMA
OXYRIOUS
3
Q
Worms presnent in both human and animals
A
FASCHIOLA
HETROPHES
4
Q
Tx antibiotic induced
PSUDO MEMBRANOUS COLITIS
A
VANCOMYCIN
5
Q
TUBUCORARIN should not be taken with
A
GENTAMYCIN
Risk of MG - dec in ACH
6
Q
Tx of methicillin resistant staph
A
VANCOMYCIN
7
Q
TRIMETOPHRIM cause which SE
A
PHOTOSENSITIVITY
Also nalidixic Acid, sulfa drugs, FQ
8
Q
Preffered over carbenicillin for CHF, Renal F, HTN
A
TICARCILLIN
Bec of small doses
9
Q
Tetracycline should not be given in
A
PREGNANCY
10
Q
Tetracycline gives different patterns of absorption/dissolution bacause it is
A
AMPHOTERIC
Forms acids/ bases
Internal salts
11
Q
Mantox test is used in
A
TB
12
Q
Tx of systemic ANAEROBIC infection
A
METRONIDAZOLE
13
Q
Sulfamethoxazole/trim blocks seq step in synthesis of
A
FOLIC ACID
14
Q
Sulfa drugs are long acting because of it’s
A
PLASMA PROTEIN BINDING
15
Q
Sulfonamides SE
A
SJS
16
Q
Causes KERNICTERUS in neonates
A
SULFISOXAZOLE
17
Q
Are not liable to destruction by heat
A
SULFA DRUGS
18
Q
Tx strep Viridans; subacute bacterial
endocarditis
A
AMPICILLIN
AMINOGLYCOSIDES
19
Q
Streptococcus pyrogens-scarlet fever
is found in
A
THROAT
20
Q
Bacterial infection:
BONE
A
STAPH AUREUS
21
Q
Bacterial infection
PSEUDOMEMBRANOUS COLITIS
A
CLOSTRIDIUM DIFICILE
22
Q
Bacterial infection
UTI, MENINGITIS
A
PSEUDOMONAS AUROGINOSA
23
Q
Used in tx of gonorrhea for patient with pencillin sensitivity or
Gonococci resistance
A
SPECTINOMYCIN
24
Q
SE of pentamidine
A
SEVERE HYPOtension
25
SE of ketoconazole
Headache
GIT
26
Safest sulf to allergic pts
SULFAMETHIZOLE
27
Rifampicin should be taken when
BEFORE MEALS
28
Test for disinfectant and germicidal action
RADIAL WALKER TEST
29
Quinolone SE
CNS STIMULATION
30
Used in tx of pinworms
PYRVINIUM PAMOATE
31
Anthelmintic that should be swallowed whole- no chewing, will cause red stool, not to be used with inflammed GIT
PYRVINIUM PAMOATE
32
PYRAZINAMIDE SE
ARTHGIA
HYPERURECEMIA
33
Cuasative organism of PURULENT BOILS in the ear
STAPH
34
Erythromycin+ WARFARIN
⬇️ warfarin concentration to half
35
Cause hemolytic anemia in G6PD
PRIMAQUINE
36
PostMENOPAUSAL vaginal infection is caused by
E. COLI
37
A non irritant bacteriostatic, sporocidal in small doses
PHENYL MERCURIC NITRATE
38
Effective as urinary analgesic
PHENAZOPYRIDINE
39
Should be taken on an epmty stomach to limit destruction by acid hydrolysis
PEN G TABLETS (PENTIDS)
40
Excretion of penicillin?
Aminoglycosides?
P- tubular
A- glumerular
41
Alternative to penicillin allergic patients
ERYTHROMYCIN
42
Otitis media & sinusitis is cause by
H. INFLUENZA, S. PNEUMONIA, MORAXELLA
43
Otitis media & sinusitis TX
1. AMOXICILLIN
2. TMP-SMZ, cefixime, cefaclor
44
Drug of choice for MONILIASIS
NYSTATIN
Candida Albicans
45
Tx of tinea capitis (oral)
GRISEOFULVIN
46
Antibiotic used in TB
STREPTOMYCIN
47
Tx of Gonoccoci
PEN G
48
Useful against G+ UTI
NITROFURANTOIN
More effective in acidic urine
49
Tx of tapeworm
NICLOSAMIDE
50
Maybe combined with vancomycin in tx of MRSA
RIFAMPICIN
51
Most suitable oral sulfisoxazole
ACETYL
52
Worm in children
OXYURIS (Pinworm)
Tx Mebendazole
53
MOA by growth by competitive antagonism
SULFONAMIDES
54
MOA cell wal synthesis
CEPHALOSPORINS
PENICILLINS
55
MOA cell membrane
PLOYMIXIN
NYSTATIN
AMPHO B
56
Microorganism dangerous to the eye
PSEUDOMONAS AURUGINOSA
57
Pencilinase resistant, used in G+ upper respiratory infection
METHICILLIN
58
Pyrazinamide and INH metabolism
ACETYLATION
59
Tx of LYME disease (Borella)
DOXYCYCLINE, TC
CEFTRIAXONE- severe
60
Ketoconazole is CI with this drugs because it decreases acidity of stomach
FAMOTIDINE
61
Parenteral/topical antifungal
AMPOTHERICIN B
62
Keteconazole interacts with
WARFARIN
ANTACIDS
CISAPRIDE
H2 BLOCKERS/ PPI's
AMPHO B
63
Cause deafness as it affect the 8th cranial nerve
KANAMYCIN
64
Increases methenamine acitivity by decreasing pH of urine
K PHOSPHATE
65
K content of Pen G K is
1.7 meq/ millU
66
Most potent anti TB
INH
67
INH cause SE
LACTIC ACIDOSIS
PERIPHERAL NEURITIS
68
Indicate bacteria in urine
NITRATES
69
Most effective against G- bacteria
& P. aurogenosa
GENTAMYCIN
70
Most effective in Alkaline urine
GENTAMYCIN
71
Most effective in acidic urine
NITROFURANTOIN/ TC
72
To prevent crystaluria by sulfonamides
PLENTY OF WATER
73
Must be refrigerated
FLUOXACILLIN
74
Salfadoxime 400mg + pyrimethamine 80 is
FANSIDAR
75
Cause of FANCONI like syndrome
EXPIRED TETRACYCLINE
76
Most common microorganism in complicated UTI
E COLI
77
Drug most most appropriate to treat GONORRHEA (in poor complianc pt)
SPECTINOMYCIN
78
H. Influenza DOC
AMPICILLIN
79
DOC e. Coli
COTRIMOXAZOLE
80
Pencillin is destroyed by
HYDROLYSIS
81
Chlamydia, legionella, helicobacter tx
CIPROFLOXACIN
82
Cirprofloxacin increase toxicity of
THEOPHYLLINE
83
Chloramphenicol is indicated for
TYPHOID FEVER
84
Chloramphenicol is a type of morph
POLYMORPHIC
85
Asymptomatic in female
Dysuria in male
CHLAMYDIA
86
Tx of meningitis
CEFTRIAXONE
CEFOTAXIM
crosses BBB
87
Drug for tapeworm
THIABENDAZOLE
88
Drug for pinworm, round worm
PYRANTEL PAMOATE
89
Whip, hookworm drug
MEBENDAZOLE
90
SE of coamoxiclav
CHOLESTATIC JAUNDICE
HEPATOTOXIC
91
Effect against pseudomonas
AMINIGLYCOSIDES
92
Legionnaire's disease tx
G+ legionella pneumophila
ERYTHROMYCIN
93
Lowest degree of toxicity, acitivity similar to ampicillin
ERYTHROMYCIN
94
Reserved for tx of gonorrhea who faul tx with penicillin, amox, TC
SPECTINOMYCIN
95
Adjunt therapy in UTI, lowers NH3 and Ph, engancing antibiotic effectiveness. SE: skin rash with alcohol intake, chelates iron- avoid
ACETOHEXAMIDE ACID (AHA)
96
Not to be taken with urine alkalinizer
CIPROFLOXACIN
97
Tx of bacterial vaginosis
METRONIDAZOLE
98
TC with longest HALFLIFE
DOXYCYCLINE
99
Will cause failure of contraceptive therapy
GRISEOFULVIN
100
Released by bacteria that causes fever
ENDOTOXINS
101
Not a side effect of aminoglycoside
ANEMIA
Tetracyclines
102
Drug of choice for UTI
Trimethoprim/Sulfamethoxazole
(TMP/SMX or Bactrim):
is often used as a first-line treatment for uncomplicated UTIs.
103
Drug NOT to use in glandular fever
AMOX
104
Drugs that worsen burns
DOXY
KETOCONAZOLE
105
Cellulitis tx
PENICILLIN
106
Renal dose adjustment needed in
CHLORAMPHENICOL
107
Pre dental surgery antibiotic
PENICILLIN
108
Decreases K levels
AMPHOTERICIN
109
Aminglycoside is contraindicated with
FUROSEMIDE
ototoxic
110
Spore destruction is heated in autoclave at
100 •C (30mins) x 3 days Moist heat
111
Required presence of gastric acid
KETOCONAZOLE
112
Antibacterial with reversible MAOi
LINEZOLID
113
INH
PAS
Hydralazine
Sulfonamides
Are metabolized by
ACETYLATION
114
B- lactam metabolism by
HYDROLYSIS
115
Antiviral drug not having active metabolites
LAMIVUDINE
116
MOA or drug class of Efavirenz
NNRTI
117
Duration of treatment for varicella zoster
7 days
118
Viral infection of nerve root
SHINGLES
119
MOA or drug class of SAQUINAVIR
PROTEASE ENZYME INHIBITOR
120
Imunization against TB, is a variable strain of mycobacterium bovis
BCG
121
Not an active immunity
DPT
122
Tx of herpes simplex encephalatis
VIDARABIN
123
Tx of herpes simplex of the eyelid/ conjuctiva
IDOXORUDINE
124
Diagnostic element(antibody) in blood for HIV is detected by
ELISA assay
125
Restriction endonuclease enzyme cut the
DNA
126
Tx of PCP- pneumocyris pneumonia in HIV
PENTAMIDINE
127
Tx of CMV
FOSCARNET
CIDOVOFIR
128
Longest duration antiviral
DIDANOSINE
129
1. Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs):
LATEZ vudine
• Lamivudine (3TC)
• Abacavir (ABC
• Tenofovir (TDF)
• Emtricitabine (FTC)
• Zidovudine (AZT
130
2. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs):
NERD
• Nevirapine
• Efavirenz
• Rilpivirine
• Doravirine
131
3. Protease Inhibitors (PIs):
LARDS navir
• Lopinavir
• Atazanavir
• Ritonavir
• Darunavir
• Saquinavir
