Pharmacology

Question 1

factors associated with serious ADR

Answer 1

PK is altered, steep dose response or adverse response relationship, toxicity within or near therapeutic range, absorb/elim via a single rate-limited pathway, low oral availability/high first-pass metabolism (a change = huge increase in dose), unusual PK , especially zero order or saturation (concentration takes off once you have reached the saturation is met) - small increments in dose with these drugs

Question 2

bioequivalence

Answer 2

approx same amt of drug gets into the body - most drugs +/- 20% except for drugs like warfarin

Question 3

other drug issues

Answer 3

diet, compliance, etc.