Flashcards in Pharmacology Deck (49)
Immunologically-mediated skin reactions are dose-dependent. True/False?
All or nothing!
Non-immunologically-mediated skin reactions can be dose-dependent. True/False?
How do urticarial drug eruptions usually arise?
IgE-mediated hypersensitivity or drug-induced mast cell degranulation
Which drugs tend to cause pustular/bullous drug reactions?
Fixed drug eruptions are well-demarcated and round. Which drugs are commonly associated with this?
What are the 3 major routes of drug administration through the skin?
What is the single most important barrier to drug administration?
Stratum corneum (made up of corneocytes)
The stratum corneum is made up similar to a "bricks and mortar" model. What are the bricks?
Corneocytes embedded in filaggrin that are held together by corneodesmosomes
The stratum corneum is made up similar to a "bricks and mortar" model. What is the mortar?
Hydrophobic layer made up of intercellular lipids
Is the stratum corneum hydrophilic or lipophilic?
Absorbs lipid-soluble (hydrophobic drugs)
The principle mechansim of drug penetration of the stratum corneum is transcellular (across the stratum corneum). True/False?
Principle mechanism is intercellular (tortuous course between corneocytes)
Drug vehicles are normally used in topical administration of drug (for local effect). What are vehicles?
Pharmacologically inactive substances that "carry" the drug
List some examples of drug vehicles
Pastes and powders
Rate of absorption of a topically administered drug = ?
J = Kp x Cv
Kp = permeability coefficient
Cv = concn of drug in vehicle
A drug must exit its vehicle if it is to penetrate the stratum corneum. True/False?
The bigger the Km of a drug, the better it will enter the skin. True//False?
Lipophilic drug in a hydrophilic vehicle absorb poorly in skin. True/False?
They absorb very well
Lipophilic drug in a lipophilic vehicle absorb very well in skin. True/False?
While they will absorb, the drug will want to remain in the lipophilic vehicle at the same time, so absorption is not great
Hydrophilic drug in a lipophilic vehicle don't absorb very well. Why?
They will make it out of the vehicle but cannot penetrate the stratum corneum because they are hydrophilic
Hydrophilic drug in a hydrophilic vehicle absorb the best of all. True/False?
They ain't going nowhere
What can enhance the absorption of a drug in skin?
What are creams?
Semi-solid emulsion of oil and water containing emulsifier and preservative
Creams are cooling and greasy. True/False?
They are cooling but not greasy
What is the danger of the preservative in creams?
What are ointments?
Semi-solid mix of grease and oil containing soft paraffin
What is the benefit of ointments?
Effective at restricting transepidermal water loss
What is the downside of ointments?
Not cosmetically attractive (very greasy)
What are lotions?
Suspension of medication in water/alcohol/other liquid
What are gels?
Thickened aqueous solutions containing high molecular weight polymers