Flashcards in Porphyrias Deck (9)
What is meant by cutaneous photosensitivity?
Abnormal skin reaction to UV, and sometimes visible, light
What is porphyria?
Hereditary disease where there is build up of porphyrins, caused by reduced enzyme activity in the haem pathway
These react with light to produce skin reactions
Name the 3 most common porphyrias
Porphoryia cutanea tarda
How does porphyria cutanea tarda arise?
Reduced activity of uroporphyrinogen decarboxylase causes build up of uroporphyrins that react with light
List symptoms of porphyria cutanea tarda
List 4 causes of porphyria cutanea tarda
How does erythropoietic protoporphyria arise?
Reduced activity of ferrochelatase causes build up of protoporphyrins
List symptoms of erythropoietic protoporphyria