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Flashcards in Pharmacology During Pregnancy Deck (16):
1

Why are NSAIDs generally contraindicated in late stage pregnancy?

Prostaglandins play a critical role in initiation of labor- contract uterine SM, promote formation of gap junctions

2

What is cervical dilation dependent upon?

Prostaglandins

3

What stimulates uterine contractions?

Prostaglandins
Oxytocin

4

What receptors modulate uterine relaxation?

β2

5

What does HELLP syndrome stand for?

Hemolysis
Elevated liver enzymes
Low platelets

6

What gel contains prostaglandin E2 and promotes cervical effacement when applied vaginally?

Dinoprostone

7

Oxytocin has no effect on cervical dilation, what is its use?

Labor induction after cervical ripening
Post partum hemorrhage

8

What agents can be given if oxytocin is ineffective at treating postpartum hemorrhage?

Ergonovine
Methylergonovine

9

What drug is most commonly used to inhibit labor?

Nifedipine

10

What β2 agonist can be used to inhibit labor? How long can this medication be used?

Terbutaline
48-72 hours (potential for serious maternal heart problems/death)

11

What is the safest NSAID to use during pregnancy?

Acetaminophen

12

How can you medically treat an abortion?

Mifepristone- progesterone antagonist
Misoprostol- prostaglandin E1 analog

13

What is generally considered the first line therapy for organic impotence?

Phosphodiesterase inhibitors

14

List 3 PDEIs.

Sildenafil
Vardenafil
Tadalafil

15

What is the MOA of PDEIs?

Block cGMP breakdown
Enhance vascular relaxation
Increase blood flow

16

What PDEIs can produce decreases in BP?

Sildenafil
Vardenafil