Pharmacology of Anterior Pituitary Hormones Flashcards Preview

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Flashcards in Pharmacology of Anterior Pituitary Hormones Deck (107)
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91

Therapeutic uses for Gonadotropin preparations

Female infertility
In vitro fertilization
Male infertility

92

Diagnostic uses of gonadotropins

1. Pregnancy diagnosis and prediction of ovulations
2. Diagnoses of diseases of reproductive systems in both males and females

93

Low levels of LH and FSH can indicate

hypogonadotropic hypogonadism

94

High levels of LH and FSH can indicate

gonadal failure

95

Menopausal gonadotropins can cause

ovarian hyperstimulation/enlargement

96

Secretion of TSH

produced in the pituitary thyrotroph

97

Regulation of TSH secretion

synthesis and secretion is stimulated by TRH; circulating thyroid hormones exert negative feedback on TSH

98

Preparation of TSH

Thyrogen (also known as thyrotropin alpha)

99

MOA of TSH preparations

Thyrogen binds to TSH receptor on normal thyroid and differentiated thyroid cancer cells and stimulates cAMP production. cAMP activates a number of steps in the thyroid hormone synthetic pathways

100

Uses of Thyrogen

for tests involved in (131)I uptake by residual thyroid gland (post-operative) and metastasized thyroid carcinoma

101

Growth Hormone Analogs

1. Somatropin (Humatrope, Serotism, Genotropin, Nutropin, Saizen)
2. Somatrem (Protropin)
3. Nutropin Depot
4. Sermorelin acetate (Geref)
5. Mecasermine rinfabate (Iplex)
6. Mecasermin (Increlex)

102

Growth Hormone Antagonists

1. Lanreotide (Somatuline) - somatostatin analog
2. Octreotide (generic, Sandostatin) - somatostatin analog
3. Pasireotide (Signifor LAR) - somatostatin analog
4. Pegvisomant (Somavert)

103

Thyroid stimulating hormone analog

Thyrotropin, recombinant human TSH (Thyrogen, Thyrotropin alfa)

104

Gonadotropin Analogs

1. Menotropins [hMG] (Menopur, Pergonal, Humegon, Repronex)
2. Chorionic gonadotropin for injection [hCG] (Pregnyl; Profasi; A.P.L.)
3. Urofollitropin (Bravelle, Metrodin, uFSH, Fortinex)
4. Follitropin-alpha (Gonal-F)
5. Follitropin-beta (Puregon, Follistim)
6. Lutropin alfa [rhLH] (Luveris)
7. Choriogonadotropin alfa (Ovidrel)

105

Gonadotropin-Releasing Hormone Analogs

1. Gonadorelin hydrochloride [GnRH] (Lutrepulse; Factrel)
2. Leuprolide acetate (Lupron, Eligard)
3. Histrelin acetate (Supprelin LA, Vantas)
4. Nafarelin acetate (Synarel)
5. Goserelin acetate (Zoladex)
6. Triptorelin pamoate (Trelstar)

106

Gonadotropin-Releasing Hormone Antagonists

1. Ganirelix (Antagon, Orgalutran)
2. Cetrorelix (Cetrotide)
3. Abarelix (Plenaxis)
4. Degarelix (Fimagon)

107

Prolactin Antagonists (Dopamine agonists)

1. Bromocriptine (Parlodel)
2. Carbegoline (Dostinex)