Pharmacology of Antiarrhythmics I Flashcards Preview

CV II Exam 3 > Pharmacology of Antiarrhythmics I > Flashcards

Flashcards in Pharmacology of Antiarrhythmics I Deck (55)
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1

procainamide

class Ia Na channel blocker

2

lidocaine

class Ib Na channel blocker

3

flecainide

class Ic Na channel blocker

4

class II antiarrhythmics

esmolol
metoprolol
propranolol

5

amiodarone

class III - K channel blocker

6

sotalol

class III - K channel blocker

7

verapamil and diltiazem

class IV - non-DHP CCB antiarrhythmics

8

ACLS drugs

adenosine
atropine
MgSO4

9

sodium gradient

both inside drive

10

potassium gradient

concentration outward
electrical inward

11

m gates

activation gates Na

12

h gates

inactivation gates Na

13

rapid depolarization

phase 0
Na perm increase

14

brief repolarization

phase 1
K efflux
Ca moves in

15

plateau phase

phase 2
Ca influx and K efflux

16

repolarization

phase 3
K efflux

17

gradual depolarization

phase 4
Na leak balanced by K efflux

18

SA node

Na current (fast)

19

AV node

Ca current (slow)

20

early afterdepolarization

interrupt phase 3

21

delayed afterdepolarization

interrupts phase 4

22

4 ways antiarrhythmics work

1 decreased phase 4 slope
2 increased threshold
3 increased max diastolic potential
4 increased action potential duration

23

class Ia

-intermediate kinetics
-decreased conduction velocity
-slow phase 0 depolarization
-increased refractoriness
-decreased autonomics

24

class Ib

-rapid kinetics
-shorten phase 3 repolarization
-no effect velocity

25

class Ic

-slow kinetics
-slow phase 0
-decreased conduction velocity
-no effect on refractoriness

26

class II

beta blocker
-prolonged AV conduction
-decrease conduction velocity
-increased refractoriness
-decreased autonomics
-decreased HR and contractility
-decreased O2 demand

27

class III

K channel blockers
-prolong phase 3 repolarization
-diminshed outward K during repolarization
-increased refractoriness
-increased AP duration

28

class IV

Ca channel blockers
-slow phase 4 depolarization and slow conduction in tissues dependent on Ca current (AV node)
-decreased conduction velocity
-increased refractoriness
-decreased autonomics

29

atrial and ventricular arrhythmias

procainamide - class Ia

30

DOC for termination of VT and prevention of VF after cardioversion

lidocaine - class Ib