Pharmacology of Skin Cancer - Sweatman Flashcards Preview

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Flashcards in Pharmacology of Skin Cancer - Sweatman Deck (27):
1

what is the MOA of Imiquimod (the primary MOA)

agonist for Toll Like Receptors, TLR 7 or 8

2

What type of skin cancer is Imiquimod indicated for?

Basal Cell Carcinoma

3

What is the route of administration of Imiquimod and why is this important?

it is applied topically
(go read over his slide about the specifics of application)
the rate of absorption and systemization of the drug is related to the concentration of the application and the surface area to which it is applied, and also how long the cream stays on the skin

4

what is a key side effect of imiquimod, let's say if you're gonna be knocking boots later

it can compromise the integrity of barrier contraception - somehow it eats through condoms

5

what is a general side effect of Imiquimod, and how should you counsel patients accordingly

increases photosensitivity - pts need to avoid direct sunlight to the treated area

6

What is the Hedgehog inhibiting drug? name

Vismodegib

7

what is an important side effect of Vismodegib, the hedgehog inhibitor

teratogenic -
male sperm also affected. so don't jizz inside her

8

why is Vismodegib, a headgehog inhibitor, teratogenic?
(this is not necessarily for memorization, just a way to help remember why Vismodegib is teratogenic)

hedgehog family of intercellular signaling proteins are key mediators in processes in embryonic development. Their activities are central to growth, patterning, and morphogenesis of many different regions within the body plans of vertebrates - so if you inhibit this pathway in the neonate, will fuck up development

9

which type of skin cancer is there no targeted therapy?

squamous cell carcinoma

10

what drug works by stimulating IL-2 mediated functions? what type of skin cancer is it used for?

Aldesleukin, used for melanoma

11

what two drugs that we talked about require regular X-ray monitoring of patients - for pulmonary shit

Aldesleukin and INF-alpha

12

What drug promotes T cell activation through the removal of negative regulatory influence from CTLA4

Ipilimumab

13

what kind of skin cancer is Ipilimumab used for

melanoma

14

what two drugs target PD1? what skin cancer are they used for?

Nivolumab and Pembolizumab
used for melanoma

15

What is a common mutation seen in melanoma?

BRAF

16

are tyrosine kinase inhibitors teratogenic?

yes

17

the use of what drugs is predicated upon determining a BRAF V600E or V600K mutation prior to starting therapy?

Vemurafenib
Dabrafenib
(sorafenib, trametinib - although they do not explicitly target BRAF)

18

in general, is genotyping required for use of kinase inhibitors

yes

19

what is the target of Trametinib

MEK1 and MEK2

20

In general, what are 4 ways resistance could arise to MAPK inhibitors? (think pathways)

accumulation of a new mutation during tumor proliferation
activation of ancillary pathways, either up or downstream of the targeted block
activation of bypass pathways
all that malarkey of pathway feedback - one pathway is active, downregulates others - if you block that pathway, then other pathways become more active

21

What is the MOA of tirchloroacetic acid? what is it used to treat

causes a chemical peel
used to treat actinic keratosis

22

is oxybenzone a chemical or filter type sunscreen

chemical

23

for measuring efficacy of sunscreen, define the critical wavelength

CW represents the wavelength at which 90% of the absorbance curve resides

24

what does the SPF labeling of a product denote?

its ability to protect the skin from sunburn

25

what is the maximum SPF value that can be ascribed a sunscreen?

50+

26

what sunscreen products can be labeled as "broadspectrum"

those that protect against both UV-A and UV-B light

27

read over the sunscreen handout, he said there would be a question coming form that

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