Pharmacology physiology Flashcards

(53 cards)

1
Q

Affinity is

A

How well a drug will bind to its receptor or binding
site.

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2
Q

High affinity means

A

The drug will more readily bind to its target at a low concentration

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3
Q

Agonist

A

Mimics the action of a naturally occurring substance

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4
Q

Antagonist

A

Blocks/inhibits the action of an agonist

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5
Q

The CNS is composed of

A

Brain and spinal cord

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6
Q

The PNS is composed of

A

The nerves that extend throughout the body

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7
Q

The somatic nervous system controls

A

Voluntary movement and sensory information

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8
Q

The autonomic nervous system controls

A

involuntary physiologic processes

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9
Q

What are the three subdivisions of the autonomic nervous system

A

Sympathetic, Parasympathetic, Enteric

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10
Q

What is a presynaptic cell?

A

A sending cell

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11
Q

What is a post synaptic cell?

A

A receiving cell

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12
Q

Fight or flight is

A

Sympathetic

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13
Q

Rest and digest is

A

Parasympathetic

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14
Q

The enteric nervous system is

A

The second brain the is embedded in the GI tract

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15
Q

Sympathetic Presynaptic preganglionic fibers are shorter because?

A

they are
located near the spinal
cord, requiring less travel
for signal transmission

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16
Q

Why are parasympathetic preganglionic fibers longer?

A

the
parasympathetic ganglia
are located near or
within the target organs,
necessitating longer
travel distances

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17
Q

The nervous system is a _____ loop system

A

closed

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18
Q

Define a negative feedback loop

A

A loop that focuses on correcting deviations to return to a set point

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19
Q

Define a positive feedback loop

A

A loop that amplifies responses rather than correcting it.

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20
Q

Name a positive feedback loop

A

Childbirth

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21
Q

Afferent neurons carry

A

Impulses from receptors to the CNS

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22
Q

Efferent neurons carry

A

Impulses from the CNS to the body

23
Q

Interneurons connect

24
Q

Alpha/beta receptors are what classification?

25
Muscarinic and nicotinic receptors are
Cholinergic
26
Name the sympathetic neurotransmitters
Epinephrine and Norepinephrine
27
Name the cholinergic neurotransmitters
Acetylcholine
28
What organ releases Epi and Norepi
Adrenal medulla
29
Where is acetylcholine released from
Parasympathetic nerve endings
30
What receptors cause vasoconstriction, pupil dilation, and smooth muscle contraction?
Alpha 1
31
What receptors inhibit norepi release?
Alpha 2
32
What receptors increase heart rate and renin secretions?
Beta 1
33
What receptors cause smooth muscle relaxation such as within the bronchioles?
Beta 2
34
What receptors promote fat breakdown and relax the bladder?
Beta 3
35
What class of medications may cause a lowered heart rate and reduce oxygen demand?
Beta blockers
36
What are some common uses of beta blockers?
Hypertension, Heart failure, Arrhythmias, angina
37
What receptors slow heart rate?
Muscarinic 2
38
What receptors trigger smooth muscle contraction in muscles and glands?
Muscarinic 3
39
What is the classification of muscarinic receptors?
G-protein coupled receptors (GPCRs) just means they activate intracellular signaling pathways when acetylcholine binds
40
What type of receptor is found at the neuromuscular junction and plays a key role in muscle contraction
Nicotinic 1
41
What type of receptor is found in autonomic ganglia and the CNS and is involved in synaptic transmission?
Nicotinic 2
42
What is the classification of nicotinic receptors?
ion channels (ligand-gated ion channels) that open when acetylcholine binds, allowing the flow of ions into the cell
43
Succinylcholine acts by
trapping muscles in the depolarizing state and thereby preventing them from receiving more impulses.
44
Vecuronium and Rocuronium act by
preventing the action of acetylcholine at the neuromuscular junction
45
What is a sympatholitic?
drug that inhibits the sympathetic nervous system
46
What is a parasympatholytic
A drug that inhibits the parasympathetic nervous system
47
Medications that relieve sensation of pain
Analgesics
48
Absence of the sensation of pain
Analgesia
49
Absence of all sensation
Anesthesia
50
Reverse effects of opioid analgesics
Opioid antagonists
51
What do opioids do?
Provide pain relief by binding to opioid receptors in the CNS
52
What is the drug class of narcan
competitive opioid receptor antagonist
53
Benzodiazepines are
CNS depressants that enhance GABA