Pharmacology Sympathetic Antagonists MOA

Question 1

Irreversiblyblocks a1 and a2 indirect baroreflex activation

Answer 1

Phenoxybenzamine

Question 2

Reversibly blocks a1 and a2

Answer 2

Phentolamine

Question 3

Blocks a1, not a2

Answer 3

Prazosin, doxazosin, terazosin

Question 4

Slightly selective for a1A

Answer 4

Tamsulosin

Question 5

Blocks a2
Elicits inc central sympathetic activity
Inc norepinephrine release

Answer 5

Yohimbine

Question 6

Blocks B and a1

B>a1 block

Answer 6

Labetalol

Question 7

Block B1 and B2

Answer 7

Propranolol
Nadolol
Timolol

Question 8

Block B1> B2

Answer 8

Metroprolol
Atenolol
Alprenolol
Betaxolol
Nebivolol

Question 9

Lower HR and BP
Reduce renin
Safer in asthma

Answer 9

Block B1> B2

MAABN
Metoprolol
Atenolol
Alprenolol
Betaxolol
Nebivolol

Question 10

Lower HR and BP
Reduce renin
Maybe CI in asthma

Answer 10

Propranolol
Nadolol
Timolol

Question 11

Lowers BP

HR rises due to baroreflex activation

Answer 11

Phenoxybenzamine

Question 12

Blocks a-mediated vasoconstriction
Lowers BP
Inc HR (baroreflex)

Answer 12

Phentolamine

Question 13

Alpha 1 selective used to lower BP

Answer 13

Prazosin
Doxazosin
Terazosin

Question 14

Blockade may relax prostatic SM more than vascular SM

Answer 14

Tamsulosin

Question 15

Lowers BP with limited HR inc

Answer 15

Labetalol

Question 16

Used for pheochromocytoma and high catecholamine states

Answer 16

Phenoxybenzamine

Question 17

Used for htn and BPH

Answer 17

Prazosin
Doxazosin
Terazosin

Question 18

Used for BPH

Answer 18

Tamsulosin
Prazosin
Doxazosin
Terazosin

Question 19

Used for male erectile dysfunction

Answer 19

Yohimbine

Question 20

Propranolol
Nadolol
Timolol used for

Answer 20

Htn
Angina pectoris
Arrhythmias
Migraine
Hyperthyroidism

Question 21

Metoprolol
Atenolol
Alprenolol
Betaxolol
Nevivolol used for

Answer 21

Angina pectoris
Hypertension
Arrhythmias

Question 22

Irreversible blocker of alpha receptors

Answer 22

Phenoxybenzamine

Question 23

Duration of effect of phenoxybenzamine

Answer 23

> 1 day

Question 24

Adv of bradycardia
Fatigue
Vivid dreams
Cold Hands

Answer 24

Metoprolol
Atenolol
Alprenolol
Betaxolol
Nevivolol

Question 25

Toxicity of propranolol Nadolol Timolol

Answer 25

``` Bradycardia Worsened asthma Fatigue Vivid dreams Cold hands ```

Question 26

Blocks B2> B1

Answer 26

Butoxamine

Question 27

Blocks B1B2 with intrinsic sympathomimetic (partial agonist) effect

Answer 27

``` Pindolol Acebutolol Carteolol Bopindolol Oxprenolol Celiprolol ```

Question 28

B > a1 block

Answer 28

Bucindolol

Question 29

B1>B2

Answer 29

Esmolol

Question 30

Blocks tyrosine hydrolase | Reduces synthesis of dopamine, norepinephrine, epineprhine

Answer 30

Metyrosinase

Question 31

Inc peripheral resistance

Answer 31

butoxamine

Question 32

Very brief cardiac blockade

Answer 32

Esmolol

Question 33

Lowers BP, modestly lowers HR

Answer 33

``` Pindolol Acebutolol Carteolol Bopindolol Oxprenolol Celiprolol Penbutolol ```

Question 34

Lowers BP | Central nervous system may elicit extrapyramidal effects (due to low dopamine)

Answer 34

Metyrosine

Question 35

No clinical indication

Answer 35

Butoxamine

Question 36

``` Pindolol Acebutolol Carteolol Bopindolol Oxprenolol Celiprolol Penbutolol ```

Answer 36

Hypertension Arrhythmias Migraiine May avoid worsening of bradycardia

Question 37

Used for heart failure

Answer 37

Carvedilol Medroxalol Bucindolol

Question 38

Rapid contorl of BP, arrythmias, thyrotoxicosis, myocardial ischemia intraoperatively

Answer 38

Esmolol

Question 39

Used for pheochromocytoma

Answer 39

Phenoxybenzamine (block a1 and a2) Phentolamine (block a vasoconstriction) Metyrosine (tyrosine hydroxylase inhibitor)

Question 40

Tyrosine hydroxylase inhibitor

Answer 40

Metyrosine

Question 41

Toxicity of butoxamine

Answer 41

Asthma provocation

Question 42

``` Toxicity of Pindolol Acebutolol Carteolol Bopindolol Oxprenolol Celiprolol Penbutolol ```

Answer 42

Fatigue Vivid dreams Cold hands

Question 43

Toxicity of Carvedilol Medoxalol Bucindolol

Answer 43

Fatigue

Question 44

Toxicity of esmolol

Answer 44

Bradycardia, hypotension

Question 45

Metyrosine toxicity

Answer 45

EPS, orthostatic hypotension, crystalluria