phenooxybenzamine Flashcards
(16 cards)
phenoxybenzamine is used to treat
pheocromocytoma= irreversibly blocks a1 and a2
parazosin, doxazosin, and terazosin are used to treat
BPH and HTN= blocks a1, but not a2
tamulosin is used to treat
BPH (no HTN treatment)= selective for a1a
yohimbine treats
male erectile disfxn and hypotension= blocks a2
labetalol is used to treat
HTN= block b and a= no reflex tachy
1st generation adrenoreceptor antagonists (4)
nonselective= b1 and b2= propranolol, nadolol, timolol, pindolol
2nd generation adrenoreceptor antagonists (5)
selective= b1 more than b2= atenolol, metapropolol, esmolol, beliprolol, acebutolol (AMEBA)
3rd generation adrenoreceptor antagonist
vasodilatory= b1=b2> a1> a2= labetolol and carvedilol
propolol, nadolol, timolol
block b1 and b2= lower hr and bp, reduce renin= treat HTN, angina, arrhythmias, migraine and hyperthyroidism
metopropolol, atenolol, alprenolol, betaxolol, nebivolol,
block b1>b2= lowers hr and bp, reduce renin, may be safer in asthma= angina, HTN, arrhythmias
pindolol, acebutolol, carteolol, penbutolol
b1, b2 w/ isa= lower bp and modestly lowers hr= HTN, arrhythmias, migraine, avoids worsening of bradycardia
carvedilol
b>a= treat heart failure
adverse affects of b adrenoreceptor antagonists
fatigue, worsening PAD, worsening bronchospasm, decreased sexual fxn, increase in diabetes, masked symptoms of diabetes
effects of b adrenoreceptor antagonist on cardiovascular system
lower bp in HTN pts, decrease hr, low av conduction, decrease myocardial o2 consumption
effects of b adrenoreceptor antagonists on respiratory tract
increased airway resistance
effects of b adrenoreceptor antagonists on metabolism and endocrine
inhibits lipolysis, decrease glucagon release, increase VLDL, decrease HDL
