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Andrenergic antagonists > phenooxybenzamine > Flashcards

Flashcards in phenooxybenzamine Deck (16)
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1

phenoxybenzamine is used to treat

pheocromocytoma= irreversibly blocks a1 and a2

2

parazosin, doxazosin, and terazosin are used to treat

BPH and HTN= blocks a1, but not a2

3

tamulosin is used to treat

BPH (no HTN treatment)= selective for a1a

4

yohimbine treats

male erectile disfxn and hypotension= blocks a2

5

labetalol is used to treat

HTN= block b and a= no reflex tachy

6

1st generation adrenoreceptor antagonists (4)

nonselective= b1 and b2= propranolol, nadolol, timolol, pindolol

7

2nd generation adrenoreceptor antagonists (5)

selective= b1 more than b2= atenolol, metapropolol, esmolol, beliprolol, acebutolol (AMEBA)

8

3rd generation adrenoreceptor antagonist

vasodilatory= b1=b2> a1> a2= labetolol and carvedilol

9

propolol, nadolol, timolol

block b1 and b2= lower hr and bp, reduce renin= treat HTN, angina, arrhythmias, migraine and hyperthyroidism

10

metopropolol, atenolol, alprenolol, betaxolol, nebivolol,

block b1>b2= lowers hr and bp, reduce renin, may be safer in asthma= angina, HTN, arrhythmias

11

pindolol, acebutolol, carteolol, penbutolol

b1, b2 w/ isa= lower bp and modestly lowers hr= HTN, arrhythmias, migraine, avoids worsening of bradycardia

12

carvedilol

b>a= treat heart failure

13

adverse affects of b adrenoreceptor antagonists

fatigue, worsening PAD, worsening bronchospasm, decreased sexual fxn, increase in diabetes, masked symptoms of diabetes

14

effects of b adrenoreceptor antagonist on cardiovascular system

lower bp in HTN pts, decrease hr, low av conduction, decrease myocardial o2 consumption

15

effects of b adrenoreceptor antagonists on respiratory tract

increased airway resistance

16

effects of b adrenoreceptor antagonists on metabolism and endocrine

inhibits lipolysis, decrease glucagon release, increase VLDL, decrease HDL