Physiology Flashcards
Adrenoreceptors
Alpha 2
Fat, platelets
Reuptake of NE
Decrease cAMP
Adrenoreceptors
Beta 1
Heart and kidney
Increase cAMP
Adrenoreceptors
Beta 2
Smooth muscle relaxation
Lungs
Increase cAMP
Cholinoreceptors
N1
Skeletal muscle
Open Na and K channels
Cholinoreceptors
N2
Adrenal medulla
Open Na and K channels
Cholinoreceptors
M1
Head and neck
Increase Ip3
Increase Ca
Cholinoreceptors
M2
Heart
Increase IP3
Increase Ca
Cholinoreceptors
M3
GI
Increase IP3
Increase Ca
Plasma Osmolarity formula
2 x plasma Na + glucose/18 + BUN/28
NaKATPase pump
TOKEN
Two K in, 3 Na out
Phenylalanine derivatives
Pare, True, Love, Does, Not, Exist, To, Me
Phenylalanine Tyrosine L-DOPA Dopamine Nor-Epinephrine Epinephrine Thyroid hormones Melanin
Enzyme needed tyrosine to L DOPA
Tyrosine Indroxylase
L Dopa to dopamine
Dopa Decarboxylase
DOPA to NE
Dopa B Hydroxylase
NE to Epi
PENMT
Tryptophan derivatives
MSN
Melatonin
Serotonin (median raphe)
Niacin
Meissners corpuscles
Fast acting type 1
Non hairy specialy fingertips and lips
Movement of objects, decrease low freq vibration
Merkel’s disc
Slow acting type 1 Expanded tip tactile receptor or IGGO done receptor Continous touch (steady staff signals) determines TEXTURE
Ruffinis end organs
Slow acting type 2
Deep skin, joints and internal tissues
Pressure, temp, degree for joint rotation
Pacinian Corpuscles
Fast acting type 2
Onion like skin deep fascia
Deep pressure, increase frequency vibration
Physiology of sleep
Stage 1
Alpha and Theta waves
Physiology of sleep
Stage 2
Theta waves, K complexes
Sleep spindles
Physiology of sleep
Stage 3
Delta + sleep spindles
Physiology of sleep
Stage 4
Delta waves
Physiology of sleep
REM
Beta waves
Physiology of sleep
Stage 1-4
<90 minutes
Physiology of sleep
REM occurs every
90 minutes
Physiology of sleep
Stage 1&2
Light sleep
Physiology of sleep
Stage 3&4
Deeper slow wave sleep
Physiology of sleep
REM description
Increase brain activity
Dreaming
Erection
Physiology of sleep
Possible cause of active inhibitory process
Muramyl peptide
Physiology of sleep
Alpha
Beta
Theta
Delta
Alpha- awake, eyes closed
Beta- awake, eyes open
Theta- brain disorders/degeneration
Delta- deep sleep, infants
Microtubules
Kinesin
Kinesin - kumakalat
Transfer substances from center to periphery
Microtubules
Dynein
Dine in
Transports substances from periphery to center
Reflection coefficient/ osmotic coefficient
O=1 a1bumin - no solute penetration
O=o Orea- complete solute penetration
Glut transporters
1- brain, RBC 2- liver and pancreas 3- brain, neurons, placenta 4- muscle and adipose (insulin requiring) 5- small intestine (luminal membrane)
Bohr effect
Due to increase Co2, O2 is delivered to body tissues
Haldane effect
Due to increase O2, CO2 expired to environment
Oxygen hemoglobin dissociation curve
Shift to the right
Increase pCO2 Increase 2,3-DPG Increase temperature Increase H Decrease pH
Respiratory lung zones
Zone 1 decrease Q and V…. Increase V/Q and O2
Zone 3 increase Q and V….. Decrease V/Q and O2
Multiple Endocrine Neoplasia
MEN 1
Werners syndrome
Parathyroid tumor
Pituitary tumor (prolactin/GH)
Pancreatic (zes, insulinomas, vipomas, glucagonomas)
Multiple Endocrine Neoplasia
MEN 2 A
Parathyroid Tumor
MTC (calcitonin)
Pheochromocytoma
Multiple Endocrine Neoplasia
MEN 2B
Oral/intestine neuromas
MTC (calcitonin)
Pheochromocytoma
Sites of absorption
Duodenum
Vitamin C
Iron
Sites of absorption
Jejunum
CHON CHO FAT water Folate
Sites of absorption
Ileum
ADEK
B12
Intrinsic factor
Bile salts
Hormone that will increase appetite
Neuroceptor Y
Ghrelin
Hormone that will decrease appetite
Peptide YY
POMC
Primary polydipsia
Decrease serum ADH Decrease serum Na Hypo osmolarity Increase urine flow \+ CH2O
Central DI
Decrease serum ADH Increase serum Na (too much water excretion ) Hypo osmolarity Increase urine flow \+ CH2O
Tx- DDAVP
Nephrogenic DI
Increase serum ADH due to increase plasma osmolarity
Increase serum Na, due to too much water excretion
Hypo urine osmolarity
Increase urine outflow
+ CH2O
Resistant to ADH
tx- thiazides
Water deprivation
Increase serum ADH Increase or normal serum Na Hyper osmolarity Decrease urine flow - CH2O
SIADH
Increase serum ADH decrease serum Na Hyper osmolarity Decrease urine flow - CH2O
Tx- demeclocyline
SIADH small cell lung CA
Trio of electrolytes
Increase H= increase Ca and K
Vice versa
Renal K regulation
Principal cells - reabsorb Na, secretes K
Intercalated Cells- reabsorb K, secretes H