Physiology of the Skin Flashcards Preview

Week 44: Rash > Physiology of the Skin > Flashcards

Flashcards in Physiology of the Skin Deck (15)
Loading flashcards...
1

4 layers of the epidermis

Stratum basale
S spinosum
S granulosum
S corneum

2

2 layers in the diffusion barrier of the skin

Protein rich corneocytes
Lipid rich intercellular material

3

Odland bodies or lamellar bodies

Produce the intercellular cement that goes between corneocytes

4

2 barriers to UV radiation

Protein barrier (stratum corneum)
Melanin barrier

5

Does UVA or UVB penetrate more deeply?

UVA

6

4 pigments involved in skin colour

Brown
Red
Blue
Yellow

7

3 functions of melanin

Protection against UV radiation
Scavenging or cytotoxic radicals
Participating in neurologic development

8

Melanosomes

Synthesized by the melanocyte
Transported along the dendrites or cell processes
Contain melanin

9

One melanocyte feeds melanin to how many keratinocytes?

~36

10

What determines skin colour?

The number of melanosomes, the size of them, and the amount of melanin in them/its degradation
NOT the number of melanocytes! We all have the same number

11

2 components of tanning
1. Immediate
2. Delayed

1. During UV exposure, redistribution of melanosomes - UVA
2. 3-4 days after UV exposure, related to increased melanocytes/dendricity/melanosomes in an SOS response to DNA damage - UVB

12

3 things that cause blotches of dark in the skin

Light
Inflammation
Chemicals/hormones

13

UV radiation needed for what hormone

Vitamin D3

14

3 ways to increase heat loss

Vasodilatation
Sweating
Decrease in thermogenesis

15

3 ways to conserve heat

Skin vasoconstriction
Piloerection
Shivering/chemical thermogenesis/thyroxine secretion