Pics 1: coag/plt/throm Flashcards
Coag, platelets, thrombosis (130 cards)
1
Q
Bethesda Assay
How it works
A
2
Q
Differentiating causes of long aPTT
Congenital vs Acquired hemophilia
Congenital +inh
Lupus inhibitor
Heparin effect
A
3
Q
Lupus inhibitor: what it acts on
A
4
Q
Mechanisms of anticoagulants, and examples
Xa
IIa
Xa and IIa
VKA
A
5
Q
Trials for APS, warfarin for triple positive
A
6
Q
Half lives of Vit K dependent factors
Why it matters
A
7
Q
Warfarin indications
A
8
Q
DOACs pros/cons
A
9
Q
DOAC reversal
A
10
Q
Anticoagulant with altered GI anatomy
A
11
Q
CAT: who can’t get DOAC
which societies?
A
12
Q
Primary, secondary hemostasis and fibrinolysis
Testing for each part
A
13
Q
Coagulation cascade
A
14
Q
Clinical scenarios: Isolated long aPTT
A
15
Q
Clinical scenarios: isolated long PT/INR
A
16
Q
Scenarios with long aPPT and PT/INR
A
17
Q
Coag testing abnormalities: summary table
A
18
Q
Hemophilia genetics
A
19
Q
Hemophilia complications
A
20
Q
Hemophilia: percentage increase with doses of FVIII or FIX
A
21
Q
Types of extended half life coagulation factor products
A
22
Q
MOA emicizumab
A
23
Q
Hemophilia rebalancing therapies
A
24
Q
Gene therapies for hemophilia
MOA?
A
25
Rare factor deficiencies table
26
HHT therapies
27
Delta/Dense granule contents
27
PFA-100
what agonists?
Simple results?
27
Vascular bleeding disorders
Also EDS
28
Steps of platelet function
28
Alpha granule contents
29
Platelet aggregometry: types of agonists
Which are strong?
30
Example plt agg
P2Y12 inh
ASA effect
30
Example plt agg
VWD2B/plt type VWD
collagen issues [GPVI]
31
Possible inherited bleeding disorder flow sheet
32
Testing modalities for platelet disorders
33
Specific disorders of platelets
Plt count
smear
aggs
other tests
which gene
34
Specific disorders of platelets
Plt count
smear
aggs
other tests
which gene
35
Inherited plt disorders:
Schema of the platelet
36
Bernard soulier vs Glanzmann
36
Storage pool defects vs signalling defects
37
Acquired plt dysfunction: meds and foods
37
Acquired platelet dysfunction: meds
38
Qualitative platelet defects
Differential of Inherited vs Acquired
39
Qualitative platelet defects
Differential of Inherited vs Acquired
In picture form
40
VWD and lab values for each type
41
VWD and inheritance
Also blood groups and effect on VWF
42
Quantitative VWD subtypes
43
Qualitative VWD subtypes
44
VWD Dx summary
Use BAT
Use newer assay than Risto if have it
Level <50% and bleeding -> VWD
DDAVP with 1h and 4h for Type 1C Dx
45
VWD Treatment summary
46
VWD diagnosis flowsheet
47
Flowsheet diagnosis of suspected Type 2B VWD
48
Type 2 VWD diagnosis recommendations
49
Type 2 VWD treatments recommendations
50
VWD diagnosis summary from slides
51
Pneumonic for VWD types
52
Type 2 VWD treatments recommendations
53
fibrin formation and degradation
53
Mechanisms picture, quantitative VWD
54
VWD table ASH SAP
55
Mechanisms picture, qualitative VWD
56
Coag cascade and corresponding lab tests
57
VWF multiyear analysis examples
58
FVIII concentrates
59
FIX concentrates
60
Bypassing agents in bleeding: table from ASH SAP
61
Rare factor deficiencies ASH SAP table
62
Normal platelet function diagram
63
Schematic of platelet function [picture]
and where disorders are involved
63
List of all inherited plt disorders
Know main categories
64
Acquired defects in platelet function
65
TTP vs aHUS
66
iTTP diagnosis
67
Prediction tools for TTP
68
Treatment pillars of TTP
69
Treatment TTP, acute inpt, acute inpt/outpt, remission
70
aHUS manifestations by organ system
71
Risk of aHUS by mutation and triggers
71
aHUS pathogenesis: complement balance beam
72
Stopping terminal complement inhibitor flow chart
73
Conditions associated with DIC
73
aHUS summary
74
Mgmt DIC
75
TMA in cancer: etiologies, 3 types
76
TMA in cancer, workup and mgmt
77
Summary slide cancer associated TMA
78
HIT activation: multiple pan cellular mechanisms
78
TMA summary slide
79
Other TMAs that are/can be complement mediated
80
Catastrophic APS
81
D-ITP vs HIT: timeline and clinical picture
81
Thrombosis types in HIT
82
4Ts score in HIT
83
Treatment HIT: 2 dos, 2 donts, 2 diagnostics
84
Warfarin induced limb gangrene
Why happens [pathophys]?
85
HIT boards review pearls
85
Anti-PF4 disorders
There are 5!
86
Pathogenesis ITP
5 mechanisms
87
1L mgmt of ITP
drug/dose/time to response/side effects
87
MOA of steroids in ITP
Multiple effects on immune system
88
2L mgmt ITP
Rx, RR, longterm remission rates
89
Drug induced ITP summary
90
ITP boards summary slide
91
Treatments summary for ITP
91
DDX TMA flowsheet
92
Complement alternative pathway
93
iTTP pathogenesis picture
94
Classifications of TMAs
Known vs unknown etiologies
95
HIT incidence by population and which drug exposed to
96
Testing for ITP
from working group recommendations
97
ITP
Primary
secondary
phases
98
PE management flow sheet
99
Recurrence triangle
with percentages
100
Recurrence triangle
with modifiers of level on triangle
101
Test in thrombophilia:
which to do
Common/classic/acquired/other
102
who to consider thrombophilia testing
103
False testing of Protein C, S, AT
Why acquired deficiency and which ones?
104
New Sydney criteria for antiphospholipid syndrome diagnosis
105
Effects of DOACs on coag testing
106
Family members: who to test when family member has a thrombophilia
107
Conditional recommendations of when to maybe test for inherited thrombophilia
108
Inherited thrombophilias summary slide
109
Threshold model of thrombosis risk
110
Factors favouring extended or limited anticoagulant therapy in patients with unprovoked VTE
111
Main questions for unexplained arterial thrombosis in the young
4 main parts/sections
112
Reasons for and against thrombophilia testing
113
Inherited thrombophilias and estimated prevalence and RR for VTE manifestations
114
Management of supra therapeutic INR in pt on VKA
115
DOACs and their properties table
