Pics 2: hemoglobinopathy

Question 1

Thalassemia summary and map

Answer 1

Question 2

Alpha thal slide
silent carrier
trait

Answer 2

Question 3

HbH disease slide

Answer 3

Question 4

Hydrops fetalis slide

Answer 4

Question 5

HbE summary

Answer 5

Question 6

Hb Lepore summary

Answer 6

Question 7

Hb Constant spring summary

Answer 7

Question 8

Thalassmias and Hbopathy summary slide overview

Answer 8

Question 9

HbH disease
symptoms
genotypes

Answer 9

Question 10

Hydrops fetalis
Pathophys of manifestations

Answer 10

Question 11

Alpha thal
Genotype:phenotype associations

Answer 11

Question 12

B thal major: pathophys and clinical features

Answer 12

Question 13

B thal genotype:phenotype assocations

Answer 13

Question 14

TDT vs NTDT full body complications

Answer 14

Question 15

Iron chelator agents
Effects on iron overload/organs
side effects/monitoring

Answer 15

Question 16

Schematic of thalassmias and their classifications

Answer 16

Question 17

Thalassemia: newer therapies and their MOA

Answer 17

Question 18

Gene therapies in Thalassemia

Answer 18

Question 19

Summary table for thalassemias vs hemoglobinopathies

Answer 19

Question 19

Hb electrophoresis and HPLC examples

Answer 19

Question 20

Sickle cell trait and SCD phenotypes

Answer 20

Question 21

SCD complications by spectrum of hemolysis/endothelial dysfunction to viscosity/vasoocclusion

Answer 21

Question 21

Pathophys of RBC sickling

Answer 21

Question 22

Management algorithm for suspected acute chest syndrome

Answer 22

Question 22

Sickle cell disease full body complications acute and chronic

Answer 22

Question 23

Mgmt of TIA or ischemic stroke in sickle cell disease by timeline of presentation

Answer 23

Question 24

Peds: TCD and stroke prevention primary vs secondary trials

Answer 24

Question 25

Acute sickle hepatopathies: mgmt

Answer 25

Question 26

General overview of SCD treatments

Answer 26

Question 26

Benefits of HU in SCD by physiology

Answer 26

Question 27

HU therapy toxicities

Answer 27

Question 27

Acute emergency transfusion indications Simple vs RCE

Answer 27

Question 28

Chronic transfusions Targets Indications for primary and secondary prevention

Answer 28

Question 29

Transfusion around elective surgery Low/Int/High risk surgery

Answer 29

Question 30

Hemoglobin structure and globins, location of production over lifespan

Answer 30

Question 31

Spectrum of thalassemias by transfusion dependence

Answer 31

Question 32

Overview of SCD stuff to know

Answer 32

Question 33

Thalassemia: Classification TDT or NTDT and management

Answer 33

Question 34

Complications TDT vs NTDT chart/table Ash SAP

Answer 34

Question 34

Pathophys flowchart of beta thal

Answer 34

Question 35

Iron chelators table ASH SAP

Answer 35

Question 36

Lab findings various Sickle Cell disease syndromes severity, Hb fractions, Hb level and MCV

Answer 36

Question 37

Important clinical trials in SCD

Answer 37

Question 37

Acute exacerbation of anemia in SCD Differential Dx

Answer 37

Question 38

Immunizations for patients with SCD

Answer 38