Pics 3: anemia/iron Flashcards by Victoria DeVito

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Hemolysis overview: hereditary vs acquired

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DAT and indirect DAT

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Ddx DAT positive

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Mechanisms of hemolysis
WAIHA
Cold AIHA

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WAIHA 1L rx

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DDX DAT neg

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Cold agglutinin syndromes:
Causes in 3 categories

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WAIHA 2L Rx

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WAIHA emerging and upcoming therapies and targets

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WAIHA 3L/4L

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AIHA types review chart

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PCH lab features

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Cold acting antibody diseases
But 1 isn’t hemolytic
CAD and PCH vs cryoglobulinemia

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Mechanisms of DI AIHA
3 mechanisms

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PNH symptoms/signs
Body diagram

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Eculizumab diagram, MOA

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Summary diagram of compliment inhibitors, including new ones

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PNH summary slide

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Anemia approach

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Hemolytic anemias
Clinical symptoms/course/complications

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B12 and folate absorption

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Various classification schemas of hemolytic anemias

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High yield teaching points: Anemia summary slide
HS
HE
G6PD
PK
megaloblastic
pernicious anemia
Copper def

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Complications of chronic hemolysis: pathophys picture

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RBC cytoskeleton and groups of membranopathies

G6PD drugs

Membraneopathy genetics HS HE/HPP

Ddx DAT patterns

Chart: immune injury to RBCs by type: Warm Ab Cold Ab Mixed Ab Drug induced hemolysis

Mechanisms of drug induced hemolytic anemias: 3 prototypical types plus protein adsorption affecting DAT

Complement cascade with inhibitors

DDX fragmentation hemolysis

Factors changing dietary iron absorption

Underproduction anemias by MCV Plus "other" category

Causes of IDA

Lab findings related to iron: normal, iron depletion, iron restricted erythropoiesis, IDA

Iron studies/Labs IDA vs AOCD

Causes B12 def

Causes folate def

Supportive care for acute porphyria

Anemia in Older adults Approach

Classification of PRCA Congenital vs acquired Different secondary causes

Algorithm for diagnosis of acute porphyrias Which are treated with Hemin? Order of lab testing?

Acute porphyrias table 4 types

Blistering cutaneous porphyria table 3 types

Nonblistering cutaneous porphyria table 2 types

Heme synthesis pathway Start where? Mitochrondial and cytosolic steps?

Iron overload Assessment of overload status and monitoring for A/Es of chelators

Chelator agents table

Hemochromatosis natural history Effects over lifetime

Consequences of free iron, oxidative stress and response to oxidative stress

HFE genotypes Common? Which can cause HH?

Hepcidin regulation By transferrin binding

Iron balance regulation Hepcidin and the liver

Intestinal iron absorption Picture with channels etc

Chelation: adverse effects

Body iron homeostasis

IV iron preparations Indications Test dose needed/black box warning?

Iron high yield teaching points: PO iron IV iron Hepcidin IRIDA Anemia of inflam HH Deferiprone Sideroblastic anemia

Iron movement in body: simplified diagram

Diet iron and absorption Modifiers of absorption

Hepatocyte and hepcidin regulation of iron

Iron mediated regulation of hepcidin

Inflammation regulation of hepcidin

Erythroferrone and hepcidin

Hepatocyte: systemic iron regulation By hepcidin By ferroportin

Iron restricted erythropoiesis picture

Manifestations of iron overload

HFE hemochromatosis summary slide

Hepcidin -> ferroportin -> iron metabolism Summary of IDA, AOCD, HH, Iron loading anemia