Platelet Inhibitors

Question 1

List cox 1 inhibitor

Answer 1

Aspirin

Question 2

List Receptor P2Y12 (ADP receptor) antagonists

Answer 2

Grel ending and tic start
Clopidogrel 
Ticragrelor 
Prasugrel
Ticloopidin

Question 3

List Glycoproteins iib/iiia receptor antagonist

Answer 3

Abciximab
Eptifibatid
Tirofiban

Question 4

Which platelet inhibitor is given IV

Answer 4

Glycoprotein iib/iiia receptor antagonist

Question 5

Aspirin first line drug for

Answer 5

First line for prevention and treatment of arterial thrombotic disorders

Question 6

Aspirin indications

Answer 6

Ischemic heart disease angina pectoris and MI
Transient cerebral ischemia
Ischemic stroke

Question 7

Unwanted aspirin effects

Answer 7

GI irritation and ulcer
Aspirin asthma
Hemorrhagic stroke

Question 8

Clopidogrel and prasugrel mechanism of action

Answer 8

Irreversibly inhibits ADP induced aggregation, both are prodrugs

Question 9

Ticragrelor difference than clopidogrel

Answer 9

Not a prodrug and binds reversible and is the only one cleared by the kidneys

Question 10

What is used in patients who can’t tolerate aspirin

Answer 10

Ticlopidine

Question 11

Ticlopidine indications

Answer 11

• patients who can’t tolerate aspirin
• prevention of transient cerebral ischemia
• prevention of stroke with prior cerebral thrombotic events

Question 12

Ticlopidine adverse effects

Answer 12

Neutropenia and agranulocytosis

Question 13

Which receptor P2Y12 antagonist is used for prevention of ischemic events

Answer 13

Clopidogrel

Question 14

Which receptor P2Y12 antagonist is used for prevention of TIA

Answer 14

ticlopidine

Question 15

Which receptor P2Y12 antagonist is used for acute coronary symptoms

Answer 15

All except ticlopidine

Question 16

Which receptor P2Y12 antagonist is used for percutaneas coronary intervention

Answer 16

All except ticlopidine

Question 17

Mechanism of action of GP iib/iiia receptor antagonist

Answer 17

Bind to receptor making a blockade of fibronogen binding to GP iib/iiia do no aggregation

Question 18

GP iib/iiia receptor antagonist clinical uses

Answer 18

Adjacent to percutaneous coronary intervention

Question 19

What can GP iib/iiia receptor antagonist be combined with

Answer 19

Combined with heparin and followed by dual antiplatelet therapy

Question 20

What do we give for ACS and PCI

Answer 20

DAPT dual antiplatelet therapy

Question 21

How long before surgery should aspirin be stopped

Answer 21

7 days

Question 22

How long before surgery should clopidogrel be stopped

Answer 22

5 days

Question 23

Thrombolytic agents mechanism of action

Answer 23

Dissolve blood clots by promoting conversion of plasminogen to plasmin

Question 24

List first generation fibrinolytics

Answer 24

Urokinase and streptokinase

Question 25

List seconds generation fibrinolytics

Answer 25

Altepase and tissue plasminogen activator

Question 26

List third generation fibrinolytics

Answer 26

Reteplase and teneceteplase

Question 27

Which thrombolytics have the longest half life

Answer 27

Alteplase and tenecteplase

Question 28

Thrombolytic agents indications

Answer 28

- Used in acute myocardial infarction within 12 hours of onset(earlier the better) - Acute thrombotic stroke

Question 29

Which fibrinolytic is fibrin selective

Answer 29

Alteplase - activates only plasminogen bound to fibrin in a thrombus

Question 30

Antidote for fibrinolytic system

Answer 30

Aminocarproic acid and tranexamic acid

Question 31

Iron replacement therapy

Answer 31

Ferrous sulfate 200-400 mg

Question 32

Acute iron intoxicity

Answer 32

Deferoxamine IV