Polycythemia Vera Flashcards Preview

Hematology > Polycythemia Vera > Flashcards

Flashcards in Polycythemia Vera Deck (5)
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1

mutations present in >95% of cases and detectable in peripheral blood leukocytes...

Jak2 mutations

2

Bone marrow smear morphology and characteristics

--Increase in megakaryocytes AND erythroid precursors...(some overla in pathogenesis of P. vera and ET, but not understood)
--Hypercellular marrow
(b/c meg and erythroid hyperplasia)

3

Clinical Presentation

Thrombosis!!!
hypertension
stroke
MI
(But Remember: Increased RBC's can also be due to lung disease!)

4

Prognosis

>10-yr. survival is common
can progress to myelofibrosis, MDS, acute leukemia

5

Immunophenotype

No known features