Essential Thrombocythemia Flashcards Preview

Hematology > Essential Thrombocythemia > Flashcards

Flashcards in Essential Thrombocythemia Deck (6)
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1

Jak2 mutations

in ~50% of cases...detectable in blood leukocytes

2

Clinical Presentation

Thrombosis
(Remember: increased platelets can also be due to iron deficiency, infection, chronic inflammation)

3

Morphology

Increased megs
(large and weird looking even for Megs!!)
Megs tend to cluster

4

Immunophenotype

No known features

5

Prognosis

>10 yrs survival is common
can progress to myelofibrosis, MDS, acute leukemia

6

Main difference b/w P.vera and ET

Megs in ET look bizarre