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Flashcards in Primary Myelofibrosis Deck (7)
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1

megs

look bizarre

2

Early Primary Myelofibrosis vs ET

VERY hard to tell apart
Reticulin stain would show more reticulin fibers in PM than in ET (early marker of fibrosis)

3

Jak2 mutation

In ~50% of cases

4

Clinical Presentation

Thrombosis
Throbocytosis and/or leuko-erythroblast picture

5

Morphology

Increased Megs
bizarre shapes
clustering
fibrosis

Very unique looking

6

Immunophenotype

No known features

7

Prognosis

Usually shorter survival than ET
Can progress to marrow failure, acute leukemia