PPQ Flashcards by Katrina Prior

Enrofloxacin belongs to

AMEG B

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for how long should a valid veterinary prescription for antimicrobial veterinary medicinal products from the date of issue, according to the new EU regulation on verterinary medicines

5 days

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gentamicin belongs to

AMEG C

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how did the veterinary antimicrobial consumption change during the last 5 years in the EU

decreased

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how would you describe the pharmacokinetic properties of colistin and gentamicin

adsorption of colistin and gentamicin are very slow from the GI tract

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ornithobacterium rhinotracheal is frequently resistant to this antibiotic

tylosin and dirofloxacin

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systemic treatment is needed in this case of otitis

suppurative otitis externa

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the agent is effective against actinobacillus suis and mycoplasma hypopneumoniae in swine

enrofloxacin IM, Tulathromycin IM, and lincomycin-spectinomycin combination IM

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this drug can be used for the treatment of foot rotm as it is active against anaerobic bacteria and its penetration is good

florfenicol and amoxicillin

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this drug can effectively be used in cystitis in dogs if its caused by enterococci or lactamase producing e. coli

amoxicillin clavulanic acid and amoxicillin

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this drug is authorised for poultry and can be effective against fowl cholera

amoxicillin

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this drug is authorised in poultry and can be effective against ulcerative enteritis

phenoxymethylpenicillin

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what is the route of admin for gamithromycin in swine

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which agent would be first line choice in chronic pharyngitis in dogs

Azithromycin

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which drug belongs to the first line systemic treatments for canine pyoderma

cefalexin

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which drug can be used for systemic treatment of MRSP pyoderma in dogs

rifampicin

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which of the following bacteria can cause polyserositis of swine

streptococcus suis

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which parameter is pharmacokinetic

Cmax

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Zinc sulphate can be used topically to treat

interdigital dermatitis

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‘single shot’ antiobiotics can be used against

BRDC

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It is inevitable to remember the pharmacodynamic properties of certain antimicrobials to be able to reduce the spreading of resistance. Based on this knowledge macrolide antibiotics are advised to use in high dosages for short period of time

false

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tulathromycin can reach effective concentration in lung and this concentration persist in lung until one week

true

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Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine, and it is outstanding activity against Mycoplasma species.

true

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Amoxicillin is authorised only for intramuscular administration in both swine and cattle.

false

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As of February 2022, the prophylactic used of antimicrobials will be limited to the individual treatment of animals.

false

most common form of antiobiotics used by veterinarians is a solution and premix

true

the spread of antimicrobial resistance can be slowd down

true

From 2022, when antibiotics are added to feed, the duration of prophylactic treatment must not exceed two weeks.

false

The efficacy of oral chlortetracycline against mycoplasmas in poultry species is uncertain due to poor absorption.

false

in poultry species, tilmicosin may be most effective in treating diseases caused by spirochaete spp

false

Oral sulphonamide-trimethoprim combinations are particularly effective against mycoplasmas in poultry species.

false

The PK/PD analysis is (AUC/MIC model) helps estimate the degree of spreading antimicrobial resistance. The higher the ratio the higher the chance is for selection of mutant bacteria resistant to the given antimicrobial agent.

false

Perform a PK/PD analysis

* Cmax/MIC in case of conc dependant (MIC has to be 8-10X higher than Cmax to achieve optimum killing speed) → plasma / tissue conc have to be 10X higher than MIC for perfect efficacy * PK analysis (liquor, lung, intestines, synovial fluid) published data -> compare drug conc at site of infection with MIC * PD MIC determination more useful (drug resistant or susceptible but give you conc which can be compare with online data in diff tissues)

Acquired resistance to fluoroquinolone in pathogenic bacteria develops gradually and, in several stages, only after several weeks of treatment.

false

It is proven, that animal products can transfer antimicrobial resistance to people, the most important and versatile vector of it is the E. coli.

true

In case of time dependent bactericidal antibiotics their maximum concentration should be at least six times higher in the treated compartment than the MIC volume of the given antibiotic agent for the given infectious bacterium isolate.

false

Multiple causes can be present in the background of BRDS, while the treatment of which the bacterial resistance is rare. Most of the empirically suitable antibiotics can treat the disease in case of P. Multocida, M. Haemolytica and M. Boris infectious background as well.

false

In case of bovine P. Multocida respiratory disease the MIC value for ceftiofur is 0.004 mg/𝞵l. The concentration reached in the PELF, in the blood and in the pulmonary interstitial fluid is higher than the MIC value for more than 8 days. This means a correct drug choice for the treatment of the infectious disease.

true

In case of ruminant Porphyromonas levii interdigital dermatitis, although the substance can be present at the site of infection in high concentrations, using tetracycline locally is not advised due to the bacterial resistance against the substance.

false

The treatment of calf E. Coli diarrhoea depends on the severity of the animal, in case of lack of systemic symptoms the usage of antibiotic agents is not advised, fluid and electrolyte therapy are recommended.

true

For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations

false

target receptor of amitraz

Octopamine rc

topically for canine pyoderma

neomycin

side effects of florphenicol

NOT KCS or anaemia- (chloramphenicol)

Which statement is true about the following sentence? Using systemic treatment is not needed in cases of intertrigo, because bacteria cannot reach deeper part of the skin in this dx

whole statement is true

general indication for AB

the product is indicated for several bacteria which are listed in the indication

NOT authorised for poultry in the EU

Chloramphenicol, gentamycin | YES: tiamulin, Tylvalosin, phenoxymethylpenicillin

Which statement is true about the following sentence? Susceptibility testing should always be performed before treating folliculitis, because bacterial susceptibility is difficult to estimate in case of deep pyodermas

whole sentence is false

this drug is very effective against fastidious bacteria and mycoplasmae as well and has excellent distribution

both of them = enrofloxacin and tulathromycin

which statement is true about foot root disease in ruminants

Interdigital dermatitis can be treated with tetracycline spray, because high, effective concentration can be reached with topical treatment at the site of infection

This drug can be used for the treatment of foot rot,as it is active against anaerobic bacteria and its penetration is good.

tulathromycin

"In PK/PD analysis for the treatment of respiratory infections,bacteria's MIC value should be compared to the drug's concentration in the...

all of them: blood plasma, urine, PELF= Pulmonary epithelial lining fluid

administration of colistin swine

Both of them= IM and PO= parenteral

in poultry, e.coli can cause

both of them: CRD + septicaemia also: granulomatosis + arthritis

which statement is true about BRDC

Fastidious organisms are the most frequent bacteria present. Luckily,resistance is usually low in them to most antibiotics.

single shot AB good for

None? = GI and foot infection | good for respiratory diseases

lincomycin in swine

Both PO and IM

Amox + claavulinic acid in swine

both: oral and parenterally

resistance rates are worse in this species

poultry

brachyspira hyodsentry what antibiotic can be used

tyvalosin

what is the pharmacodynamic? Cmax/MIC/both/none

Both

amoxicilin can be used against clostridia perfringens C,E. rhusiopathiae, streptocouss

all 3

antimicrobial resistance cannot be slowed down

false

mastitis good general condition, treat with intramammary infusion

true

most common form of use of medicine by vet injection

false premix + oral powder

plasmid e.coli strain in poultry

false (pigs)

as of February 2022, prophylaxis use is not allowed

false

antimicrobial in feed no longer than 2 weeks

false- 5 days for antimicrobials and 2 weeks for AB and 1 month for when not specified on the veterinary product

in ruminants fusobacterium necrophorum locally is good but systemically treatment with amoxicillin clavulanic IV

false- lincomycin, tulathromycin and fluorophenol

which drug can be found in high concentrations in macrophages

macrolides

disc diffusion method something about it cannot be used in PK/PD method

performing AB susceptibility

Bovine respiratory disease complex, M. Bovis hard to eradicate and treat, 3 drugs tulathromycin, Gamithromycin and enrofloxacin. Can be used for treatment?

true

what is florfenicol

AMEG C

what is marbofloxacin

AMEG B

colistin should be decreased by 95% in coming years

False 65%

question about metaphylaxis/prophylaxis allowed under current rules: food producing, small, allowed or not

allowed

use of fluorquinolones is prohibited in poultry

false (resistant though)

single shot of AB can be used against: GI, foot rot, both, none

NOT: GI, skin, mastitis YES: respiratory

what drug is used in canine pyoderma: cefovecin, amoxicillin, both, none

both

gentamicin + colistin

absorption of colistin + gentamycin is very low from GI tract

AM consumption

decreased

PQ vet prescription

5 days

concentration dependent bactericidal max conc. should be 6 times higher

false

how would you determine conc in pneumonia with AB spectrum: PELF, blood plasma, urine, all 3

PELF

e. coli in calves AB susceptibility- faecal sample, severe cases blood test

true

MRSA know which systemic and which is topical

Local: mupirocin, Fusidic acid Systemic: rifampicin, amikacin, florfenicol, chloramphenicol

tylvasin belongs to

macrolides

ceftiofur belongs to

3rd generation cephalosporin (beta-lactamase AB/ time dep bactericidal/ inhibition of cell wall synthesis)

severe mastitis

IV: flouroquinolones (marbofloxacin, enrofloxacin), tetracyclines, potentiated sulphonamides

can you use colistin in poultry

yes

how to tx a cow in drying off stage if no mastitis present

SCC is normal then give a bismuth seal (into teat canal) with combination of disenfection

should CIA drugs only be used in emergency/severe circumstances?

yes they are used as a last resort

PPQ Flashcards

(92 cards)