PRE ADME, PROTOX 2 AND TOXINPRED

Question 1

What are the key differences between PreADMET, ToxinPred, and ProTox-II?

Answer 1

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PreADMET

Focus: ADMET properties + Toxicity prediction for small molecules

Predicts: Absorption, Distribution, Metabolism, Excretion, and Toxicity

Includes drug-likeness filters like Lipinski’s Rule of Five

Used in early drug discovery

ToxinPred

Focus: Peptide toxicity prediction

Identifies: Toxic/non-toxic peptides

Allows design of safer peptides

Geared toward peptide research

ProTox-II

Focus: Oral toxicity prediction for small molecules

Predicts: LD50 values, hepatotoxicity, mutagenicity, carcinogenicity

Uses machine learning models