PREFINAL LECTURE L2: NORMAL HEMOSTASIS Flashcards
(438 cards)
ECs secrete VWF when activated by
vasoactive agents (e.g. thrombin)
Explain hemostasis book based
Hemostasis is a complex physiologic process that keeps circulating blood in a fluid state and then, when an injury occurs, produces a clot to stop the bleeding, confines the clot to the site of injury, and finally dissolves the clot as the wound heals.
(similar answer is acceptable)
When hemostasis system is out of balance, what 2 conditions could be life threatening?
- Hemorrhage (uncontrolled bleeding)
- Thrombosis (pathologic clotting)
The absence of a single plasma procoagulant
may destine the individual to what 3 lifelong consequences?
- Anatomic hemorrhage
- Chronic inflammation
- Transfusion dependence
If this is absent, it would allow coagulation to proceed unchecked, and cause diseases such as thrombosis, stroke, pulmonary embolism, deep vein thrombosis, cardiovascular events.
control protein
Hemostasis involves the interaction of what 3 processes to stop bleeding?
- Vasoconstriction
- Platelet adhesion and aggregation
- Coagulation enzyme activation
The key cellular elements of hemostasis are?
- Cells of the vascular intima
- Extravascular tissue factor (TF) bearing cells
- Platelets
The plasma components/protein that play a role in hemostasis include the
(answer in general term)
- Coagulation and fibrinolytic proteins
- Their inhibitors
It refers to the role of blood vessels and platelets in the initial response to a vascular injury or to the commonplace desquamation of dying or damaged
endothelial cells.
Primary hemostasis
It describes the activation of a series of coagulation proteins in the plasma, mostly serine proteases, to form a fibrin clot.
Secondary hemostasis
End product of primary hemostasis
platelet plug formation
End product of secondary hemostasis
platelet clot
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Procoagulant substances exposed or
released by damaged or activated
endothelial cells
primary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
The activator, tissue factor, is exposed on cell membranes
secondary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Delayed, long-term response
secondary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Rapid, short-lived response
primary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Involves vascular intima and platelets
primary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Involves coagulation system and platelets
secondary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Activated by desquamation and
small injuries to blood vessels
primary hemostasis
Based on table 35.1, identify if PRIMARY or SECONDARY hemostasis:
Activated by large injuries to blood
vessels and surrounding tissues
secondary hemostasis
In primary hemostasis, the blood vessels contract for what purpose?
- Seal the wound
- Reduce the blood flow (vasoconstriction)
Arrange the following events in primary hemostasis:
A) Platelets secrete the contents of their granules
B) Platelets adhere to the site of injury
C) Platelets become activated
D) Platelets aggregate with other platelets to form a platelet
plug
C, B, A, D
Vasoconstriction and platelet plug formation comprise the initial, rapid, short-lived response to vessel damage. However, in order to control major bleeding in the long term, the plug must be reinforced by?
fibrin
Enumerate examples of defects in primary hemostasis.
- Collagen abnormalities
- Thrombocytopenia
- Qualitative platelet disorders
- von Willebrand disease