Prescribing Flashcards
(29 cards)
what can decrease stomachs acidity with old age?
senescence of parietal cells
PPI use
what is the rule with acid/alkali drugs?
LIKE DISSOLVES LIKE
examples of acidic drugs?
phenytoin
aspirin
penicillin
examples of alkali drugs?
diazepam
morphine
what binds acidic drugs? does it decrease with age?
albumin
YES
what binds alkali drugs? does it decrease with age?
alpha 1 glycoprotein
no
why do lipophilic drugs stay in the body longer?
increased fat and decreased muscle
what happens in starvation mode?
lipophilic drugs are released from fat
can reach toxic levels
why are hydrophilic drugs more potent?
decreased body volume
why can hepatic metabolism be decreased?
decreased…
liver size
blood flow
disease
why can renal excretion be decreased?
decreased.. GFR size blood flow tubular secretion
what should be used to measure creatinine in elderly?
creatinine clearance
why is serum creatinine not measured in elderly?
proportionate to muscle bulk
drug- drug interactions
theophylline and macrolides
tricyclic anti depressants and type 1 anti arrythmia drugs
statins and macrolides/fibrates
causes?
rhabdomyalsis
ACE and SU causes?
hypos
clopidogrel and PPIs causes?
PPIs decrease action of clopidogrel
what can grapefruit juice be used for? what does it cause?
Vit C
cytochrome P450 inducer
what can gingko biloba be used for? what does it cause?
dementia
anticoag
what can saw pilmetto be used for? what does it cause?
BPH
anticoag
what can glucosamine juice be used for? what does it cause?
OA
hyperglycaemia
what can st jons wort be used for? what does it cause?
depression
decreases effectiveness of OCP and simvastatin
what do people with parkinsons have a higher risk of?
drug induced confusion
what drugs exaccerbate HF?
TZD
NSAIDs
COX 2 inh
