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Flashcards in Prescribing in Pregnancy Deck (20)
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1
Q

what drug does not cross the placenta

A

Heparin

2
Q

how might absorption be affected in pregnancy

A

may be affected by morning sickness

3
Q

how might distribution be affected in pregnancy

A

increased plasma volume and fat stores

- volume of distribution increases

4
Q

what other changes in pharmacokinetics are seen in pregnancy

A

Decreased protein binding
- Increased free drug

Increased liver metabolism of some drugs i.e. Phenytoin

Elimination of renally excreted drugs increases
- Increased GFR

5
Q

what period is the foetus at greatest teratogenic risk

A

between 4th and 11th week

6
Q

why is the foetus at a great teratogenic risk during this time

A

organogenesis

- product of organs

7
Q

what are some teratogenic drugs

A
ACEi/ARB
Androgens
Anti-epilpetics
Cytotoxics
Lithium
Methotrexate
Retinoids
Warfarin
8
Q

what does taking ACEi/ARB cause in pregnancy

A

renal hypoplasia

9
Q

what are frequent seizures during pregnancy associated with

A

lower verbal IQ in child, hypoxia, bradycardia, antenatal death, maternal death

10
Q

what drugs should be avoided when treating epilepsy in pregnancy

A

valproate

phenytoin

11
Q

what drug used to treat diabetes is not safe to use during pregnancy

A

Sulfonylureas

- convert to insulin

12
Q

Tx for nausea and vomiting

A

cyclizine

13
Q

what antibiotic cannot be used in pregnancy

A

gentamicin

14
Q

what is prophylaxis for DVT

A

LMWH

15
Q

what drugs cause problems via breastfeeding

A

Amiodarone – neonatal hypothyroidism
Cytotoxics – bone marrow suppression
Benzodiazepines – drowsiness

16
Q

what trimester does BP need to be closely monitored

A

2nd trimester

17
Q

what antibiotic can cause staining of bones and teeth in children

A

tetracycline

18
Q

what anti epileptic drug is particular associated with cleft palate

A

phenytoin

19
Q

what anti epileptic drug is particular associated with neural tube defects

A

valproate

20
Q

what are examples of neural tube defects

A

spina bifida

anencephaly