Principal Features of Selected CD molecules Flashcards Preview

Immunology 2.0 > Principal Features of Selected CD molecules > Flashcards

Flashcards in Principal Features of Selected CD molecules Deck (3):
1

CR1 (CD35)

  • Principal cells:
    • Granulocytes
    • monocytes
    • erythrocytes
    • B cells
    • Follicular dendritic cells,
    • some T cells
  • Principal cell functions:
    • binds C3b and C4b
    • promotes phagocytosis of C3b- or C4b- coated particles and immune complexes
    • regulates complement activation 

2

CR2 (CD21)

  • Principle cells:
    • Mature B cells
    • Follicular dendritic cells
  • Principle cells 
    • Receptor for complement fragment C3b
    • Forms a coreceptor complex with CD19 and CD81 that delivers activating signals in B cells
    • Receptor for Epstein-Barr virus 

3

CR3 (Mac-1, CD11b) 

  • Principle cells
    • Granulocytes
    • Monocytes
    • macrophages
    • dendritic cells
    • NK cells
  • Principle functions
    • Phagocytosis of iC3b coated particles
    • neutrophil and monocyte adhesion to endothelium (binds CD54) and extracellular matrix proteins