principles Flashcards
what is the difference between endotoxins and exotoxins
Exotoxins are secreted by bacteria where as endotoxins are only released following lysis of the cell.
EXO G+
ENDO G-
when does cleavage occur?
24 hours
when does implantation occur?
day 6
what is gastrulation and when does it occur?
gastrulation is the formation of germ layers, which occurs at week 3
where does the primitive streak occur?
the caudal end of the epiblast
what does the hypoblast form?
endoderm
what does the epiblast form?
ectoderm
what will the notochord become?
spinal cord
When does the intraembryonic coelom form and what does it divide into?
week 3, visceral and lateral plate
what body cavities does the coelom divide into?
pleural, peritoneal and pericardial cavity
when does the normal heart start to develop?
week 4
the first cells of the heart and start germ layer they are derived from
cardiac progenitors, derived from the visceral layer of lateral mesoderm
what does the 1st and 2nd heart field give rise to?
1st- right and left atria, and LV
2nd- RV and outflow tract
when does looping of heart occur
day 23
name regions of the heart tube after day 23 and how they move into position and what they give rise to
truncus arteriosus- aorta and PT
bulbus cordis- outflow tract + Trabeculated part of RV (moves ventral, caudal and right)
ventricle- Trabeculated LV (moves left)
atria- Trabeculated LA and RA
sinus venosus- smooth part of RA, coronary sinus (moves dorsal and cranial)
what structure allows communication between RA and LA until birth
foramen ovale
name 2 atrial septa and their character
septum primum (flexible) septum secondum (rigid)
when does the septum primum form and its direction of growth
day 30
grows down towards endocardial cushion
Name of gap between septum primum and endocardial cushion
primary ostiem/ foramen
when does the septum secondum form and position compared to septum primum
day 33
to right of SP
what is the valve of the foramen ovale formed by?
septum primum
what does the foramen ovale become in adult
fossa ovalis
conditions associated with teratology of the fallot
pulmonary stenosis, RV hypertrophy ventricular septal defect, over riding aorta, patent ductus arteriosus
describe 2 ventricular septa
membranous- grows down from endocardial cushion
muscular- grows up from ventricle