Principles of Chemotherapy

Question 1

Alkylating agents

Answer 1

Cyclophosphamide, ifosfamide, carmustine

Question 2

Platinum coordinating complexes

Answer 2

Cisplatin, carboplatin, oxaliplatin

Question 3

Folic acid analogues

Answer 3

Methotrexate, pralatrexate, pemetrexed, leucovorin

Question 4

Thymine analogue

Answer 4

5-fluorouracil

Question 5

Fluoropyrimidine analogue

Answer 5

Capecitabine

Question 6

Cytidine analogue

Answer 6

Cytosine arabinoside, gemcitabine

Question 7

Adenosine analogues

Answer 7

6-mercaptopurine, 6-thioguanine

Question 8

Blockers of tubulin polymerization

Answer 8

Vinblastine, vincristine

Question 9

Prevention of microtubule disassembly

Answer 9

Paclitaxel, docetaxel

Question 10

DNA topoisomerase I inhibitor

Answer 10

Camptothecin

Question 11

Antibiotics

Answer 11

Doxorubicin: DNA interaction
Daunorubicin: DNA intercalation

Question 12

DNA topoisomerase II inhibitor

Answer 12

Etoposide, tenoposide

Question 13

Other natural products

Answer 13

Bleomycin: generates free radicals
Hydroxyurea: inhibits ribonucleotide synthesis
Arsenic trioxide: causes oxidative damage, apoptosis

Question 14

Tyr kinase inhibitors

Answer 14

Gefitinib, erlotinib, afatinib, osimertinib

Question 15

Anti-HER2 MAb

Answer 15

Trastuzumab

Question 16

Anti-PDGFR-alpha MAb

Answer 16

Olaratumab

Question 17

BRAF inhbitors

Answer 17

Vemurafenib

Question 18

MEK inhibitor

Answer 18

Trametinib

Question 19

JAK inhibitor

Answer 19

Ruxolitinib

Question 20

BTK inhibitor

Answer 20

Ibrutinib: 1st gen
Acalabrutinib: 2nd gen

Question 21

BCR-ABL kinase inhibitor

Answer 21

Imatinib

Question 22

mTOR inhibitors

Answer 22

Sirolimus, everolimus, temsirolimus

Question 23

Anti-VEGFR MAb

Answer 23

Bevacizumab

Question 24

VEGF trap

Answer 24

Afibercept

Question 25

CTLA-4 blocker

Answer 25

Ipilimumab

Question 26

PD-1/PD-L1 inhibitors

Answer 26

Nivolumab, pembrolizumab, atezolimumab

Question 27

Recombinant IL-2

Answer 27

Aldesleukin

Question 28

Proteasome inhibitor

Answer 28

Bortezomib

Question 29

Anti-CD20 MAb

Answer 29

Rituximab

Question 30

HDAC inhibitor

Answer 30

Panobinostat

Question 31

Glucocorticoids

Answer 31

Prednisone, dexamethasone

Question 32

Anti-estrogens

Answer 32

Tamoxifen

Question 33

Aromatase inhibitors

Answer 33

Formestane, exemestane: type 1 Aminoglutethemide, anastozole, letrozole: type 2

Question 34

Androgen receptor antagonists

Answer 34

Enzalutamide, biculatamide, flutamide

Question 35

Androgen synthesis inhibitors

Answer 35

Ketoconazole, abiraterone