Tumor Suppressors and Associated Cancers Flashcards
(8 cards)
1
Q
Rb
A
Retinoblastoma, osteosarcoma
2
Q
p53
A
Li-Fraumeni syndrome
Many cancers
3
Q
APC
A
Familiar adenomatous polyposis, colorectal cancer
Gardner syndrome: add osteomas
Turcot syndrome: add CNS tumors
4
Q
CDH1
A
Familial gastric carcinoma
5
Q
SMAD
A
Pancreatic and colorectal cancer
6
Q
NF-1
A
Type 1: benign neurofibromas, cafe con leche spots, Lisch nodules
Type 2: Schwannoma of acoustic nerve (germline) or meningioma/ependymoma (somatic mutation)
7
Q
VHL
A
Renal cell cancers, pheochromocytoma, hemangioblastoma
8
Q
WT1
A
Wilms tumor (nephroblastoma)
