prokinetic agents

Question 1

prokinetic agents increase ___ and ___ of the GI tract

Answer 1

increase tone and motility of GI tract

Question 2

prokinetic agents treat

Answer 2

GERD; CINV; diabetic gastroparesis

Question 3

prokinetic agents ) Metoclopramide [Reglan, Maxolon, Octamide block receptors for ___ and __ in the CTZ

Answer 3

block serotonin and dopamine receptor

Question 4

prokinetic agents ) Metoclopramide [Reglan, Maxolon, Octamide increase ___ GI motility and suppresses ____

Answer 4

increase upper GI motility and suppresses emesis

Question 5

Cisapride [Propulsid] is also another ___ agent

Answer 5

prokinetic agent

Question 6

prokinetic agent Metoclopramide [Reglan]
Therapeutic uses when taken PO include

Answer 6

Diabetic gastroparesis and suppression of gastroesophageal reflux

Question 7

prokinetic agent Metoclopramide [Reglan]
Therapeutic uses when taken IV include

Answer 7

Promotes gastric emptying. Suppression of postoperative nausea and vomiting, suppression of CINV, facilitation of small bowel intubation, and facilitation of radiologic examination of GI tract

Question 8

adverse effects of prokinetic agents when taken in high dose therapy include

Answer 8

Sedation, diarrhea common

Question 9

adverse effects of prokinetic agents when taken as a long term high dose therapy can cause

Answer 9

Can cause irreversible tardive dyskinesia (TD)