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BIOCHEMISTRY > PROTEINS > Flashcards

PROTEINS Flashcards

1
Q

Most abundant and functionally diverse molecules in living systems:

A. Carbohydrates
B. Proteins
C. Lipids
D. Nucleic acids
E. None of these

A

B. Proteins

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2
Q

It is considered as the building blocks of proteins:

A. Purines and pyrimidines
B. Monosaccharides
C. Amino acids
D. Nucleotides
E. Fatty acids and glycerol

A

C. Amino acids

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3
Q

The following describes peptide bond, except:

A. Has a partial double bond characteristics
B. – C(=O)NH–
C. undergoes hydrolytic reaction
D. Formed by the –COOH of an amino acid and the –NH2 of the next amino acid

A

C. undergoes hydrolytic reaction

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4
Q

Which of the following statements about amino acids is correct?

A. Acidic amino acids bear a positive charge at pH = 7.0
B. All amino acids have a chiral carbon
C. Lysine and arginine are basic amino acids
D. All of these

A

C. Lysine and arginine are basic amino acids

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5
Q

Which of the following amino acids contains basic side chain?

A. Histidine
B. Arginine
C. Leucine
D. All of these
E. Both A and B

A

E. Both A and B

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6
Q

Which of the following amino acids do not contain an alipathic side chain?

A. Glycine
B. Valine
C. Proline
D. Leucine
E. Alanine

A

C. Proline

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7
Q

Which amino acid is a major neurotransmitter in the brain?

A. Tyrosine
B. Glutamate
C. Aspartate
D. Serine
E. Tryptophan

A

B. Glutamate

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8
Q

All of the following amino acid contains –OH group except?

A. Histidine
B. Serine
C. Threonine
D. Tyrosine

A

A. Histidine

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9
Q

Which of the following is a sulfur-containing amino acid?

A. Aspartatic acid
B. Asparagine
C. Methionine
D. Glutamic acid
E. Glutamine

A

C. Methionine

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10
Q

Which of the following is an example of basic amino acid?

A. Proline
B. Histidine
C. Tryptophan
D. Phenylalanine
E. Tyrosine

A

B. Histidine

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11
Q

All listed below are aromatic amino acid, except:

A. Histidine
B. Proline
C. Tryptophan
D. Tyrosine
E. Phenylalanine

A

B. Proline

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12
Q

Which of the following has a ketogenic metabolic fate?

A. Leucine
B. Tyrosine
C. Glycine
D. Isoleucine
E. Phenylalanine

A

A. Leucine

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13
Q

Which of the following amino acids contain(s) side chains with sulfur atom?

A. Methionine
B. Cysteine
C. Cytosine
D. Both A and B
E. Both A and C

A

D. Both A and B

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14
Q

Which of the following amino acid has an imino group?

A. Proline
B. Valine
C. Leucine
D. Isoleucine
E. Tyrosine

A

A. Proline

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15
Q

Which of the following amino acid possess a phenolic hydroxyl group?

A. Serine
B. Threonine
C. Tyrosine
D. Both A and B
E. All of these

A

C. Tyrosine

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16
Q

Serotonin, a neurotransmitter is derived from the amino acid ____:

A. Tryptophan
B. Threonine
C. Tyrosine
D. Phenylalanine

A

A. Tryptophan

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17
Q

Identification test for the presence of alpha amino acid and free amino groups?

A. Millon’s Test
B. Xathoproteic Test
C. Hopkin’s Cole Test
D. Ninhydrin Test
E. Molisch Test

A

D. Ninhydrin Test

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18
Q

Identification test for the presence of sulfur such as in cysteine and methionine?

A. Pauly diazo Test
B. Basic Lead Test
C. Hopkin’s Cole Test
D. Biuret Test
E. Salkowski’s Test

A

B. Basic Lead Test

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19
Q

The pH midway between the pKa values in either side of isoelectric species where amino acids exists as neutral species is called as ________.

A. pH determination
B. Henderson-Hasselbach equation
C. Isoelectric point
D. Buffer capacity of amino acids

A

C. Isoelectric point

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20
Q

Calculate the pI of alanine, pK1 (R-COOH) = 2.35; pK2 (R-NH3+) = 9.69

A

6.02

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21
Q

________ are molecules that contain an equal number of ionizable groups of opposite charges and therefore bear a zero net charge.

A. Isoelectric point
B. Amphotheric
C. Neutral amino acid
D. Zwitterions
E. Hydrophobic amino acid

A

D. Zwitterions

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22
Q

Which of the following pairs of amino acid with the indicated side chain is correctly matched?

I. Tryptophan – indole
II. Tyrosine – phenol
III. Arginine – guanidine

A. I, II and III
B. II and III only
C. I and III only
D. I and II only

A

A. I, II and III

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23
Q

The R group of the amino acid “D” is?

A. Hydroxyethyl
B. Hydroxymethyl
C. Carboxyethyl
D. Carboxymethyl
E. Methyl

A

D. Carboxymethyl

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24
Q

Sanger’s Reaction is also known as ____________.

A. Edman’s Test
B. Enzymatic cleavage
C. Dideoxychain termination
D. Splicing

A

C. Dideoxychain termination

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25
Q

This structure of peptides refers to the order of amino acids in the polypeptide chain/s and the location of disufide bonds:

A. Primary
B. Secondary
C. Tertiary
D. Quaternary

A

A. Primary

26
Q

The overall spatial arrangement of amino acid residues close to one another in the linear sequence of a polypeptide chain:

A. Primary
B. Secondary
C. Tertiary
D. Quaternary

A

D. Quaternary

27
Q

Secondary Structure includes:

A. Loops
B. Turns
C. Bends
D. B and C only
E. All of these

A

E. All of these

28
Q

The overall arrangement and interrelationship of various regions or domains, and individual amino acid residues of a single polypeptide chain is ____ structure.

A. Primary
B. Secondary
C. Tertiary
D. Quaternary

A

C. Tertiary

29
Q

It can prevent the misfolding of nascent polypeptide chain:

A. Proteasome
B. Chaperone
C. Histone
D. Enzymes
E. Hormones

A

B. Chaperone

30
Q

Non – protein molecules that are often associated with proteins are called:

A. Prosthetic group
B. Side chain
C. Zwitterions
D. Casein

A

A. Prosthetic group

31
Q

Protein denaturation:

A. Usually irrreversible
B. Unfolding and disorganization of the protein structure
C. Often insoluble (in the form of precipitate)
D. Caused by heat, strong acids & strong base
E. All of these

A

E. All of these

32
Q

Denaturation of protein is a result of:

A. Cleavage of the peptide bond
B. Formation of hydrogen bond
C. Breakage of hydrogen bond
D. Formation of phosphodiester bond

A

C. Breakage of hydrogen bond

33
Q

An important protein in contractile muscle:

A. Keratin
B. Myosin
C. Elastin
D. Fibrin
E. Collagen

A

B. Myosin

34
Q

Alzheimer’s Disease:
A. Genetic defects that impair the synthesis of one polypeptide sub-units of hemoglobin (beta sheet)
B. Glutamic acid is replaced by a valine in the amino acid sequence
C. Misfolding of b - amyloid in human brain tissue

A

C. Misfolding of b - amyloid in human brain tissue

35
Q

In collagen formation, the amino acids proline and lysine need further modification. What modification is done to these amino acids?

A. Acetylation
B. Methylation
C. Epoxidation
D. Hydroxylation
E. Sulfation

A

D. Hydroxylation

36
Q

It can stabilize the triple helix structure of collagen

A. Methionine
B. Valine
C. Hydroxyproline
D. Isoleucine
E. Glycine

A

C. Hydroxyproline

37
Q

Collagen Disease includes the following, except:

A. Ehler’s Danlos Syndrome
B. Menke’s Disease
C. Emphysema
D. Osteogenesis imperfecta
E. Scurvy

A

C. Emphysema

38
Q

Fibrous proteins are elongated, water – soluble, generally in either alpha-helical, pleated sheet or triple helical forms. Which listed below is an example of fibrous proteins?

A. Hemoglobin
B. Actin
C. Myosin
D. Elastin
E. Both A and B

A

D. Elastin

39
Q

Major hemoglobin present on adult?

A. a2b2
B. a2g2
C. a2S2
D. a2d2
E. None of these

A

A. a2b2

40
Q

The product obtained from partial hydrolysis of collagen:

A. Myosin
B. Gelatin
C. Actin
D. Fibrinogen
E. Thrombin

A

B. Gelatin

41
Q

Which of the following is incorrect about carbon monoxide?

A. Irreversible
B. Fatal
C. Binds tightly with Hb (HbCO)
D. Carbon monoxide poising can be treated with oxygen

A

A. Irreversible

42
Q

2, 3-bisphosphoglycerate:

A. Also known as 2, 3-diphosphoglycerate
B. Most abundant organic phosphate in the red blood cells
C. Favors/stabilizes the T form
D. Increase concentration is seen on emphysema, high altitudes
E. All of these

A

E. All of these

43
Q

Xanthoproteic test is a test for:

A. Free amino groups
B. Cysteine
C. Arginine
D. Tyrosine
E. Methionine

A

D. Tyrosine

44
Q

The ordered steps in protein synthesis is:

I. Activation
II. Elongation
III. Initiation
IV. Termination

A. I – II – III – IV
B. III – II – I – IV
C. I – III – II – IV
D. II – III – I – IV

A

C. I – III – II – IV

45
Q

Which of the following vitamins is present in coenzymes required in the transfer of amino groups and decarboxylation of amino acids? Its deficiency state is manifested by glossitis, peripheral neuropathy and niacin deficiency:

A. Pyridoxine
B. Niacin
C. Thiamine
D. Riboflavin

A

C. Thiamine

46
Q

Dialysis is a method of separating proteins on the basis of:

A. Size
B. Solubility
C. Charge
D. Albumin

A

A. Size

47
Q

The proteins that make fur, wool, claws and feathers:

A. Collagen
B. Silk
C. Keratin
D. Elastin
E. Sulfur

A

C. Keratin

48
Q

The ribosomal subunit that binds with the initiation complex is ____.

A. 30s
B. 50s
C. 70s
D. 80s
E. 100s

A

A. 30s

49
Q

Deficiency of this substance favors elastin degradation, thus leads to destruction of the alveolar walls of the lungs resulting to emphysema:

A. a- keratin
B. desmosine crosslink
C. a-1 antitrypsin
D. ascorbate

A

C. a-1 antitrypsin

50
Q

Which of the following is present on all connective tissues?

A. Mucoids
B. Lipids
C. Albuminoids
D. All
E. None

A

A. Mucoids

51
Q

Death due to cyanide poisoning results from:

A. Cyanide – hemoglobin complex formation
B. Cyanide – combining with RBC
C. Cyanide – inhibiting cytochrome oxidase
D. Coronary vessel occlusion

A

C. Cyanide – inhibiting cytochrome oxidase

52
Q

When oxygen binds to hemoglobin, which of the following does it displace in the normal individual?

A. CO
B. CO2
C. CH3
D. Fe+2
E. Fe+3

A

B. CO2

53
Q

Which of the following symptoms is most closely related to methemoglobinemia?

A. Cyanosis
B. Myopathy
C. Raynaud’s Syndrome
D. Chest pains
E. Both A and B

A

A. Cyanosis

54
Q

Denaturation usually destroys all of the following bonds in protein, except:

A. Hydrogen bonds
B. Covalent bonds
C. Hydrophobic bonds
D. Electrostatic bonds

A

B. Covalent bonds

55
Q

The amino acid that contributes to the tertiary structure of a protein by causing a bend when it occurs in the primary sequence is:

A. Leucine
B. Alanine
C. Proline
D. Tyrosine
E. Aspartic acid

A

C. Proline

56
Q

A mucin is which of the following types of proteins?

A. Simple protein
B. Phosphoprotein
C. Chromoprotein.
D. Nucleoprotein.
E. Glycoprotein

A

E. Glycoprotein

57
Q

Streptomycin is an antibiotic which inhibits the process of:

A. Translation in eukaryotes
B. Translation in prokaryotes
C. DNA replication in prokaryotes
D. Transcription in eukaryote
E. Transcription in prokaryotes

A

B. Translation in prokaryotes

58
Q

Each of the following represents an amino acid found in proteins and used directly in the reactions of protein synthesis, except:

A. Proline
B. Arginine
C. Tryptophan
D. Asparagine
E. Hydroxylysine

A

E. Hydroxylysine

59
Q

Most ________ amino acids are buried away from the water solvent that interacts with the surface of a soluble protein while most ____ side-chains are on the surface of soluble globular proteins:

A. Charged – Hydrophobic
B. Hydrophobic – Charged
C. Hydrophobic – Polar
D. Charged – Polar

A

C. Hydrophobic – Polar

60
Q

Which amino acid is antagonized by drugs of abuse such as ketamine and phencyclidine and is implicated in schizophrenia:

A. Glycine
B. Aspartate
C. Tryptophan
D. Glutamate
E. Tyrosine

A

D. Glutamate

BIOCHEMISTRY (12 decks)

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