Proteolysis and Blood Coagulation Flashcards Preview

Elements of Medicine > Proteolysis and Blood Coagulation > Flashcards

Flashcards in Proteolysis and Blood Coagulation Deck (14):
1

What are the three ways clotting is regulated?

Factors are diluted by blood, liver takes out active factors, factors degrade by proteases (negative feedback of kvllikrein on 12 and thrombin activating antithrombin and Protein C).

2

What are the three roles of platelets?

surface for clotting factors (flip inner leaflet), provide clotting factors, aggregate to block area

3

What proteins are activated by proteolysis?

CBPD
collagen, blood clotting factors, protein hormones, digestive enzymes

4

What are the four properties of proteolytic activation?

allows enzymes to be circulating inactive, irreversible, have to inactivated by antiproteases, rapid activation to site of action

5

Riveraxaban

anti factor 10

6

Warfarin

inhibits vitamin K recycling into active form, inhibiting vitamin K dependent factors 2, 7, 9, 10

7

Aspirin

Factor 13 inhibitor

8

Clopidogrel

inhibits platelets

9

Dobigotren

competitive inhibitor thrombin

10

Heparin

activates antithrombin

11

Antithrombin inhibits

Factors 9-12

12

Which factors activate 7?

12, 9, and 10

13

When does kallikrein inhibit Factor 12?

When 12 is all 12a , kallikrein binds to another active site to take 12 to 12f.

14

Trypsin has been accidentally activated in the pancreas. . How does the pancreas protect itself?

PTI (pancreatic trypsin inhibitor). Binds competitively to the trypsin active site. Inflexibly binding into a complex that is later digested. This complex is inactive.