Flashcards in Proteolysis and Blood Coagulation Deck (14):
What are the three ways clotting is regulated?
Factors are diluted by blood, liver takes out active factors, factors degrade by proteases (negative feedback of kvllikrein on 12 and thrombin activating antithrombin and Protein C).
What are the three roles of platelets?
surface for clotting factors (flip inner leaflet), provide clotting factors, aggregate to block area
What proteins are activated by proteolysis?
collagen, blood clotting factors, protein hormones, digestive enzymes
What are the four properties of proteolytic activation?
allows enzymes to be circulating inactive, irreversible, have to inactivated by antiproteases, rapid activation to site of action
anti factor 10
inhibits vitamin K recycling into active form, inhibiting vitamin K dependent factors 2, 7, 9, 10
Factor 13 inhibitor
competitive inhibitor thrombin
Which factors activate 7?
12, 9, and 10
When does kallikrein inhibit Factor 12?
When 12 is all 12a , kallikrein binds to another active site to take 12 to 12f.