Psoriasis Flashcards Preview

10. Dermatology > Psoriasis > Flashcards

Flashcards in Psoriasis Deck (15)
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1

What is psoriasis caused by? (2)

Give examples of each.

Genetics, e.g.
-PSORS 1-19 (chromosome 6)
-HLA genes

Environmental factors, e.g.
-Stress
-Trauma
-Current infection
-Drugs

2

List 3 examples of drugs that might provoke psoriasis.

Beta blockers
Antimalarials
Lithium

3

Describe the clinical features of psoriasis. (4)

Salmon pink plaques with silvery scale (hyperkeratosis)

Nail changes, e.g.
-Onycholysis
-Nail pitting
-Subungual hyperkeratosis

4

Describe the distribution of skin plaques in psoriasis. (4)

Scalp (including ears)
Extensor surfaces (e.g. elbows)
Axillary area
Genital area

5

Describe the pathophysiology of psoriasis. (3)

1. T cell mediated autoimmune disease

2. Psoriasis results in abnormal infiltration of T cells in the skin, causing:
a. Release of inflammatory cytokines (e.g. IFN, IL, TNF)

3. This causes proliferation of keratinocytes (hyperkeratosis)

6

List 5 types of psoriasis.

Briefly describe what each one looks like.

Plaque psoriasis
Guttate psoriasis (tear drop)
Pustular psoriasis
Erythrodermic psoriasis (inflam and erythema on 90+% body surface)
Palmar/plantar pustulosis

7

Which 2 types of psoriasis may present with an acutely unwell patient?

Which type is technically not psoriasis? Why is it grouped with the others anyway?

ACUTELY UNWELL PATIENTS:
Pustular psoriasis
Erythrodermic psoriasis

NOT PSORIASIS:
Palmar/plantar pustulosis (BUT acts like psoriasis/responds to psoriasis treatment)

8

List 4 conditions which are associated with psoriasis.

Psoriatic arthritis
Metabolic syndrome
Liver disease/alcohol misuse
Depression

9

List 5 possible types of psoriatic arthritis.

Asymmetrical inflammatory arthritis
Symmetrical polyarthritis
Predominant distal interphalangeal joint arthritis
Psoriatic spondylitis
Arthritis mutilans

10

List 3 conditions included in the metabolic syndrome.

Cardiovascular disease
Hypercholesterolaemia
Diabetes

11

How would you manage psoriasis? (3)

Assessment of severity
Topical treatments
Systemic treatments

12

List 6 types of topical treatment for psoriasis.

Moisturisers
Topical steroids
Vitamin D analogues (e.g. calcitriol, calcipotriole)
Coal tar
Topical retinoids (e.g. acitretin, tazarotene)
Phototherapy light treatment

13

List 5 types of systemic treatment for psoriasis.

Immunosuppression (e.g. methotrexate, cyclosporine)
Oral retinoids (e.g. acitretin)
Hydroxycarbamide
Fumaric acid esters
Biologic therapy (e.g. infliximab, etanercept, adalumimab)

14

List 4 methods of assessing severity of psoriasis.

% body area affected
DQLI (dermatology quality of life index)
PASI (psoriasis area severity index)
PEST (psoriasis epidemiology screening tool)

15

Describe the classification of severity of psoriasis according to % body area affected.

Mild: <3%
Moderate: 3-10%
Severe: 10+%