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10. Dermatology > Skin and Systemic Disease > Flashcards

Flashcards in Skin and Systemic Disease Deck (23)
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1

List 5 types of systemic disease which can cause skin changes.

Endocrine disease
Internal malignancy
Nutritional deficiency
Systemic infection
Systemic inflammatory disease

2

List the 4 main endocrine problems which can cause skin changes.

Thyroid problems
Diabetes mellitus
Steroid imbalance
Sex hormone imbalance

3

List common skin changes in thyroid disorders. Consider:

a) Hypothyroidism (2)
b) Grave's disease (2)

HYPOTHYROIDISM:
Dry skin
Pretibial myxoedema

GRAVE'S DISEASE:
Thyroid dermopathy
Thyroid acropachy

4

List 5 types of skin changes seen in diabetes mellitus.

Necrobiosis lipoidica
Diabetic dermopathy
Scleredema diabeticorum
Leg ulcers
Granuloma annulare

5

List 4 clinical features of necrobiosis lipoidica.

Waxy appearance
Yellow discolouration
Ulceration
Scarring

6

List 4 clinical features of scleredema diabeticorum.

Spongy, thickened skin
Warm, red, inflamed skin
Non-pitting oedema
Shawl distribution

7

List 3 clinical features of granuloma annulare.

Circular red lesions
Raised lesions
Widespread

8

List 6 skin changes often seen in Cushing's syndrome.

What is Cushing's syndrome?

Steroid excess

Erythema
Gynaecomastia
Acne
Striae
Purpura with minor trauma (easy bruising)
Global skin atrophy (skin thinning)

9

List 2 skin changes seen in Addison's disease.

What is Addison's disease?

Steroid insufficiency

Hyperpigmentation
Acanthosis nigracans

10

List some common skin changes caused by sex hormone imbalance. Consider:

a) Testosterone excess (2)
b) Progesterone excess (2)

TESTOSTERONE:
Acne
Hirsutism

PROGESTERONE:
Acne
Dermatitis

11

List 6 skin changes which can be seen with internal malignancies.

Necrolytic migratory erythema
Erythema gyratum repens
Acanthosis nigracans
Erythema annulare
Sweet's syndrome
Sister Mary Joseph nodule

12

List 4 clinical features of necrolytic migratory erythema.

What type of cancer is it most strongly associated with?

Ring-shaped red, scaly plaques
Itching
Pain
Progression of plaques through blistering, erosion and crusting

Islet cell tumours in pancreas

13

List 4 clinical features associated with erythema gyratum repens.

Which type of cancer is most strongly associated with it?

Red, concentric bands
Whorled woodgrain pattern
Severe itching
Peripheral eosinphilia

Lung cancer

14

List 2 clinical features of acanthosis nigracans.

Which type of cancer is most strongly associated with it?

Pigmented skin
Velvety feel

GI adenocarcinomas (60% gastric)

15

List 4 clinical features associated with Sweet's syndrome.

Increased WCC
Sudden onset fever
Pain
Red, well-defined plaques and papules

16

Define a "Sister Mary Joseph nodule".

Metastasis of cancer to the umbilicus, usually spreading from advanced peritoneal adenocarcinoma

17

Which 3 types of nutritional insufficiencies are most commonly associated with skin changes?

Vitamin B deficiencies
Zinc deficiency
Vitamin C deficiency

18

Which 3 types of skin change are associated with vit B deficiency?

State the specific vitamin B which causes it.

Dermatitis (B6)
Angular chelitis (B12)
Pellagra (B3)

19

Which 1 type of skin change is associated with zinc deficiency?

Acrodermatitis enterpathica

20

List 7 clinical features associated with vitamin C deficiency.

Punctate purpura
Corkscrew curly hairs
Patchy hyperpigmentation
Dry skin
Dry hair
Poor wound healing
Inflamed gums

21

List 6 causes of erythema nodosum.

IBD
Infection (esp. streptococcus)
Pregnancy
OCP
Sarcoidosis
Drug induced

22

What is erythema nodosum?

Bruise-like swellings on the shins

23

List 3 causes of pyoderma gangrenosum.

Inflammatory bowel disease, e.g.
Crohn's disease
Ulcerative colitis

Rheumatoid arthritis
Myeloma